| Date | Game | Result | Notes |
| 9/3/2005 | UNC vs. Shockers | W 100-66 | Nassau, Bahamas |
| 9/4/2005 | UNC vs. Wreckers | W 106-85 | Nassau, Bahamas |
| 11/4/2005 | UNC vs. Fayetteville State | W 94-58 | Exhibition |
| 11/12/2005 | UNC vs. Catawba | W 89-63 | Exhibition |
| 11/19/2005 | UNC vs. Gardner-Webb | W 83-80 | |
| 11/22/2005 | UNC vs. Cleveland State | W 112-55 | |
| 11/25/2005 | UNC vs. UC-Santa Barbara | W 83-66 | |
| 11/29/2005 | UNC vs. Illinois | L 64-68 | |
| 12/3/2005 | UNC @ Kentucky | W 83-79 | |
| 12/7/2005 | UNC vs. St. Louis | W 75-63 | |
| 12/17/2005 | UNC vs. Santa Clara | W 76-58 | |
| 12/21/2005 | UNC @ Southern California | L 59-74 | |
| 12/28/2005 | UNC vs. UNC-Asheville | W 89-47 | |
| 1/3/2006 | UNC vs. Davidson | W 82-58 | |
| 1/7/2006 | UNC vs. N.C. State | W 82-69 | |
| 1/10/2006 | UNC @ Virginia Tech | W 64-61 | |
| 1/14/2006 | UNC vs. Miami | L 70-81 | |
| 1/19/2006 | UNC @ Virginia | L 68-72 | |
| 1/22/2006 | UNC @ Florida State | W 81-80 | |
| 1/25/2006 | UNC vs. Boston College | L 74-81 | |
| 1/28/2006 | UNC vs. Arizona | W 86-69 | |
| 2/2/2006 | UNC @ Maryland | W 77-62 | |
| 2/4/2006 | UNC vs. Clemson | W 76-61 | |
| 2/7/2006 | UNC vs. Duke | L 83-87 | |
| 2/12/2006 | UNC @ Miami | W 80-70 | |
| 2/15/2006 | UNC vs. Georgia Tech | W 82-75 | Tyler Hansbrough ACC freshman record 40 points |
| 2/19/2006 | UNC @ Wake Forest | W 83-72 | |
| 2/22/2006 | UNC @ N.C. State | W 95-71 | |
| 2/26/2006 | UNC vs. Maryland | W 81-57 | |
| 3/1/2006 | UNC vs. Virginia | W 99-54 | |
| 3/4/2006 | UNC @ Duke | W 83-76 | |
| 3/10/2006 | UNC vs. Virginia | W 79-67 | ACC Tournament: Greensboro, NC |
| 3/11/2006 | UNC vs. Boston College | L 82-85 | ACC Tournament: Greensboro, NC |
| 3/17/2006 | UNC vs. Murray State | W 69-65 | NCAA R64 - Dayton, OH |
| 3/19/2006 | UNC vs. George Mason | L 60-65 | NCAA R32 - Dayton, OH |
| | | Record: 23-8 | |