| Date | Game | |
| Fri Feb 17, 4:00 ET | vs Binghamton Clemson, S.C. | W 11-3 |
| Sat Feb 18, 1:00 ET | vs Binghamton Clemson, S.C. | W 3-2 |
| Sun Feb 19, 1:00 ET | vs Binghamton Clemson, S.C. | W 19-1 |
| Tue Feb 21, 4:00 ET | vs Charlotte Clemson, S.C. | W 9-5 |
| Fri Feb 24, 4:00 ET | vs UCF Clemson, S.C. | L 2-4 |
| Sat Feb 25, 1:00 ET | vs UCF Clemson, S.C. | L 7-10 |
| Sun Feb 26, 1:00 ET | vs UCF Clemson, S.C. | L 6-13 |
| Tue Feb 28, 4:00 ET | at USC Upstate Spartanburg, S.C. | L 3-6 |
| Fri Mar 3, 6:00 ET | vs South Carolina Clemson, S.C. | W 5-2 |
| Sat Mar 4, 1:00 ET | vs South Carolina Greenville, S.C. | L 9-11 |
| Sun Mar 5, 1:30 ET | at South Carolina Columbia, S.C. | L 1-7 |
| Tue Mar 7, 4:00 ET | vs ETSU Clemson, S.C. | W 4-1 |
| Wed Mar 8, 4:00 ET | vs Presbyterian College Clemson, S.C. | W 5-3 |
| Fri Mar 10, 4:00 ET | vs Georgia State Clemson, S.C. | W 9-8 |
| Sat Mar 11, 1:00 ET | vs Georgia State Clemson, S.C. | W 10-2 |
| Sat Mar 11, 5:00 ET | vs Georgia State Clemson, S.C. | W 10-7 |
| Tue Mar 14, 4:00 ET | vs College of Charleston Clemson, S.C. | W 4-3 |
| Sat Mar 18, 1:00 ET | vs Duke Clemson, S.C. | L 2-3 |
| Sat Mar 18, 5:00 ET | vs Duke Clemson, S.C. | W 14-9 |
| Sun Mar 19, 1:00 ET | vs Duke Clemson, S.C. | L 8-11 |
| Tue Mar 21, 6:00 ET | vs Winthrop Clemson, S.C. | W 8-5 |
| Wed Mar 22, 6:00 ET | at Kennesaw State Kennesaw, Ga. | W 6-2 |
| Fri Mar 24, 6:00 ET | at Georgia Tech Atlanta, Ga. | L 3-4 |
| Sat Mar 25, 4:00 ET | at Georgia Tech Atlanta, Ga. | L 3-16 |
| Sun Mar 26, 2:30 ET | at Georgia Tech Atlanta, Ga. | W 14-5 |
| Tue Mar 28, 6:00 ET | vs College of Charleston Columbia, S.C. | W 10-3 |
| Thu Mar 30, 7:00 ET | vs Wake Forest Clemson, S.C. | L 3-8 |
| Fri Mar 31, 6:00 ET | vs Wake Forest Clemson, S.C. | L 3-4 |
| Sat Apr 1, 2:00 ET | vs Wake Forest Clemson, S.C. | L 3-4 |
| Tue Apr 4, 6:00 ET | vs Coastal Carolina Clemson, S.C. | W 16-6 |
| Thu Apr 6, 8:00 ET | at Florida State Tallahassee, Fla. | L 1-5 |
| Fri Apr 7, 6:00 ET | at Florida State Tallahassee, Fla. | W 8-1 |
| Sat Apr 8, 2:00 ET | at Florida State Tallahassee, Fla. | W 6-2 |
| Tue Apr 11, 7:00 ET | at Georgia Athens, Ga. | W 8-1 |
| Fri Apr 14, 8:00 ET | vs Notre Dame Clemson, S.C. | L 4-10 |
| Sat Apr 15, 4:00 ET | vs Notre Dame Clemson, S.C. | W 5-1 |
| Sun Apr 16, 1:00 ET | vs Notre Dame Clemson, S.C. | W 6-4 |
| Tue Apr 18, 6:30 ET | vs Georgia Clemson, S.C. | L 4-5 |
| Fri Apr 21, 6:00 ET | at NC State Raleigh, N.C. | W 10-2 |
| Sat Apr 22, 7:00 ET | at NC State Raleigh, N.C. | W 9-7 |
| Sun Apr 23, 2:00 ET | at NC State Raleigh, N.C. | W 8-5 |
| Tue Apr 25, 6:00 ET | vs Kennesaw State Clemson, S.C. | W 15-5 |
| Fri Apr 28, 2:00 ET | at Boston College Brighton, Mass. | W 9-7 |
| Fri Apr 28, 5:32 ET | at Boston College Brighton, Mass. | L 1-3 |
| Sat Apr 29, 12:00 ET | at Boston College Brighton, Mass. | W 6-3 |
| Fri May 5, 4:00 ET | vs Louisville Clemson, S.C. | W 6-3 |
| Sat May 6, 2:00 ET | vs Louisville Clemson, S.C. | W 4-3 |
| Sun May 7, 12:00 ET | vs Louisville Louisville, Ky. | W 7-3 |
| Wed May 10, 6:00 ET | at Coastal Carolina Conway, S.C. | W 13-6 |
| Fri May 12, 4:00 ET | at Virginia Tech Blacksburg, Va. | W 15-4 |
| Sat May 13, 7:00 ET | at Virginia Tech Blacksburg, Va. | W 9-8 |
| Sun May 14, 3:00 ET | at Virginia Tech Blacksburg, Va. | W 9-6 |
| Tue May 16, 4:00 ET | vs USC Upstate Clemson, S.C. | W 12-2 |
| Thu May 18, 6:00 ET | vs North Carolina Clemson, S.C. | W 14-7 |
| Fri May 19, 6:00 ET | vs North Carolina Clemson, S.C. | W 5-4 |
| Sat May 20, 1:00 ET | vs North Carolina Clemson, S.C. | W 3-1 |
| Wed May 24, 7:00 ET | vs Virginia Tech Durham, N.C. | W 14-5 |
| Fri May 26, 11:00 AM ET | vs Boston College Durham, N.C. | W 4-1 |
| Sat May 27, 1:00 ET | vs North Carolina Durham, N.C. | W 10-4 |
| Sun May 28, 12:00 ET | vs Miami Durham, N.C. | W 11-5 |
| Fri Jun 2, 1:00 ET | vs Lipscomb Clemson, SC | W 12-5 |
| Sat Jun 3, 6:00 ET | vs Tennessee Clemson, SC | L 5-6 |
| Sun Jun 4, 12:00 ET | vs Charlotte Clemson, SC | L 2-3 |