| Date | Game | |
| Fri Feb 16, 4:00 ET | vs Xavier Clemson, SC | W 14-3 |
| Sat Feb 17, 2:00 ET | vs Xavier Clemson, SC | W 8-3 |
| Sun Feb 18, 1:00 ET | vs Xavier Clemson, SC | W 11-7 |
| Tue Feb 20, 4:00 ET | vs Presbyterian Clemson, SC | W 8-2 |
| Fri Feb 23, 5:00 ET | vs Kennesaw State Clemson, SC | L 1-18 |
| Sat Feb 24, 2:00 ET | vs Kennesaw State Clemson, SC | W 8-6 |
| Sun Feb 25, 2:00 ET | vs Kennesaw State Clemson, SC | W 7-2 |
| Tue Feb 27, 4:00 ET | vs USC Upstate Clemson, SC | W 12-6 |
| Sat Mar 2, 2:00 ET | vs South Carolina Segra Park / Columbia, SC | W 5-4 |
| Sun Mar 3, 2:00 ET | vs South Carolina Clemson, SC | W 5-4 |
| Wed Mar 6, 6:00 ET | vs Kansas State Clemson, SC | W 8-3 |
| Fri Mar 8, 2:00 ET | vs UNC Greensboro Clemson, SC | W 12-5 |
| Sat Mar 9, 4:00 ET | vs UNC Greensboro Clemson, SC | W 9-5 |
| Sun Mar 10, 2:00 ET | vs UNC Greensboro Clemson, SC | W 6-3 |
| Tue Mar 12, 4:00 ET | vs Manhattan Clemson, SC | W 13-1 |
| Wed Mar 13, 4:00 ET | vs Manhattan Clemson, SC | W 5-1 |
| Fri Mar 15, 6:00 ET | at Duke Durham, NC | L 2-5 |
| Sat Mar 16, 3:00 ET | at Duke Durham, NC | W 8-7 |
| Sun Mar 17, 1:00 ET | at Duke Durham, NC | W 8-6 |
| Tue Mar 19, 6:00 ET | vs Winthrop Clemson, SC | W 13-3 |
| Wed Mar 20, 6:00 ET | at Presbyterian Clinton, SC | W 11-1 |
| Sat Mar 23, 1:00 ET | vs Florida State Clemson, SC | W 15-5 |
| Sat Mar 23, 5:00 ET | vs Florida State Clemson, SC | W 9-8 |
| Sun Mar 24, 1:00 ET | vs Florida State Clemson, SC | W 14-12 |
| Thu Mar 28, 7:00 ET | at Miami Coral Gables, FL | L 2-3 |
| Fri Mar 29, 7:00 ET | at Miami Coral Gables, FL | W 3-2 |
| Sat Mar 30, 1:00 ET | at Miami Coral Gables, FL | W 7-0 |
| Tue Apr 2, 6:00 ET | vs USC Upstate Fluor Field / Greenville, SC | W 11-1 |
| Fri Apr 5, 4:30 ET | at Notre Dame South Bend, IN | W 7-3 |
| Sat Apr 6, 5:30 ET | at Notre Dame South Bend, IN | W 3-2 |
| Sun Apr 7, 1:00 ET | at Notre Dame South Bend, IN | W 13-12 |
| Tue Apr 9, 6:00 ET | vs USC Upstate Clemson, SC | L 5-9 |
| Fri Apr 12, 6:00 ET | vs NC State Clemson, SC | L 8-11 |
| Sat Apr 13, 8:00 ET | vs NC State Clemson, SC | L 0-4 |
| Sun Apr 14, 1:00 ET | vs NC State Clemson, SC | W 7-0 |
| Tue Apr 16, 5:00 ET | vs Charlotte Clemson, SC | W 8-5 |
| Fri Apr 19, 6:00 ET | vs Pitt Clemson, SC | W 6-4 |
| Sat Apr 20, 1:00 ET | vs Pitt Clemson, SC | L 4-8 |
| Sat Apr 20, 4:00 ET | vs Pitt Clemson, SC | W 9-2 |
| Tue Apr 23, 5:00 ET | at Georgia Athens, Ga. | L 3-4 |
| Fri Apr 26, 6:00 ET | at Louisville Louisville, KY | W 12-11 |
| Sat Apr 27, 1:00 ET | at Louisville Louisville, KY | L 6-7 |
| Sun Apr 28, 4:00 ET | at Louisville Louisville, KY | W 17-7 |
| Fri May 3, 12:00 ET | vs Georgia Tech Clemson, SC | W 11-4 |
| Fri May 3, 3:30 ET | vs Georgia Tech Clemson, SC | L 12-14 |
| Sun May 5, 1:00 ET | vs Georgia Tech Clemson, SC | W 9-3 |
| Tue May 7, 6:00 ET | at Charlotte Truist Field / Charlotte, NC | W 14-12 |
| Fri May 10, 6:00 ET | at Wake Forest Winston-Salem, NC | L 2-4 |
| Sat May 11, 4:00 ET | at Wake Forest Winston-Salem, NC | L 5-8 |
| Sun May 12, 12:00 ET | at Wake Forest Winston-Salem, NC | L 3-13 |
| Fri May 17, 1:00 ET | vs Boston College Clemson, SC | W 11-6 |
| Fri May 17, 6:00 ET | vs Boston College Clemson, SC | ACCNX |
| Sat May 18 | vs Boston College Clemson, SC | ACCN |
| Sat May 18, 12:00 ET | vs Boston College Clemson, SC | |
| Sat May 18, 12:00 ET | vs Boston College Clemson, SC | |