| Date | Game | |
| Fri Feb 13, 4:00 ET | vs Army West Point Clemson, S.C. | W 3-2 |
| Sat Feb 14, 12:00 ET | vs Army West Point Clemson, S.C. | W 10-0 |
| Sat Feb 14, 4:00 ET | vs Army West Point Clemson, S.C. | W 7-0 |
| Tue Feb 17, 4:00 ET | vs Charlotte | ACCNX |
| Fri Feb 20, 4:00 ET | vs Bryant | ACCNX |
| Sat Feb 21, 2:00 ET | vs Bryant | ACCNX |
| Sun Feb 22, 1:00 ET | vs Bryant | ACCNX |
| Tue Feb 24, 4:00 ET | vs Presbyterian Clemson, S.C. | ACCNX |
| Fri Feb 27, 7:00 ET | at South Carolina Columbia, S.C. | SECN+ |
| Sat Feb 28, 3:00 ET | vs South Carolina Columbia, S.C. (Segra Park) | ACCNX |
| Sun Mar 1, 3:00 ET | vs South Carolina Clemson, S.C. | ACCNX |
| Wed Mar 4, 6:00 ET | vs Michigan State Greenville, S.C. | |
| Fri Mar 6, 4:00 ET | vs La Salle Clemson, S.C. | ACCNX |
| Sat Mar 7, 12:00 ET | vs La Salle Clemson, S.C. | ACCNX |
| Sat Mar 7, 4:00 ET | vs La Salle Clemson, S.C. | ACCNX |
| Sun Mar 8, 1:00 ET | vs La Salle Clemson, S.C. | ACCNX |
| Tue Mar 10, 6:30 ET | vs Georgia Southern North Augusta, S.C. | |
| Thu Mar 12, 7:00 ET | vs Georgia Tech Clemson, S.C. | ACCN |
| Fri Mar 13, 4:00 ET | vs Georgia Tech Clemson, S.C. | ACCN |
| Sat Mar 14, 3:00 ET | vs Georgia Tech Clemson, S.C. | ACCNX |
| Tue Mar 17, 6:00 ET | at College of Charleston Mount Pleasant, S.C. | FloCollege |
| Wed Mar 18, 7:00 ET | at The Citadel Charleston, S.C. | ESPN+ |
| Fri Mar 20, 4:30 ET | at Notre Dame South Bend, Ind. | |
| Sat Mar 21, 2:00 ET | at Notre Dame Notre Dame, Ind. | |
| Sun Mar 22, 1:00 ET | at Notre Dame Notre Dame, Ind. | |
| Tue Mar 24, 6:00 ET | vs Coastal Carolina Clemson, S.C. | ACCN |
| Thu Mar 26, 7:00 ET | vs Miami Clemson, S.C. | ACCN |
| Fri Mar 27, 7:00 ET | vs Miami Clemson, S.C. | ACCN |
| Sat Mar 28, 3:00 ET | vs Miami Clemson, S.C. | ACCNX |
| Wed Apr 1, 6:30 ET | vs Wake Forest Charlotte, N.C. (Truist Field) | |
| Fri Apr 3, 9:05 ET | at Stanford Stanford, Calif. | ACCNX |
| Sat Apr 4, 5:05 ET | at Stanford Stanford, Calif. | ACCNX |
| Sun Apr 5, 4:05 ET | at Stanford Stanford, Calif. | ACCNX |
| Mon Apr 6, 9:00 ET | at Santa Clara Santa Clara, Calif. | ESPN+ |
| Fri Apr 10, 6:00 ET | vs North Carolina Clemson, S.C. | ACCNX |
| Sat Apr 11, 2:00 ET | vs North Carolina Clemson, S.C. | ACCNX |
| Sun Apr 12, 12:30 ET | vs North Carolina Clemson, S.C. | ESPN2 |
| Tue Apr 14, 6:05 ET | at Charlotte Charlotte, N.C. (Truist Field) | |
| Thu Apr 16, 7:00 ET | at Virginia Charlottesville, Va. | ACCN |
| Fri Apr 17, 6:00 ET | at Virginia Charlottesville, Va. | ACCNX |
| Sat Apr 18, 1:00 ET | at Virginia Charlottesville, Va. | ACCNX |
| Tue Apr 21, 7:00 ET | vs USC - Upstate Clemson, S.C. | ACCNX |
| Fri Apr 24, 6:00 ET | at Louisville Louisville, Ky. | ACCNX |
| Sat Apr 25, 7:00 ET | at Louisville Louisville, Ky. | ACCN |
| Sun Apr 26, 2:00 ET | at Louisville Louisville, Ky. | ACCN |
| Fri May 1, 6:00 ET | vs Boston College Clemson, S.C. | ACCNX |
| Sat May 2, 2:00 ET | vs Boston College Clemson, S.C. | ACCNX |
| Sun May 3, 1:00 ET | vs Boston College Clemson, S.C. | ACCNX |
| Tue May 5, 6:00 ET | at Coastal Carolina Conway, S.C. | ESPN+ |
| Fri May 8, 6:00 ET | vs Florida State Clemson, S.C. | ACCNX |
| Sat May 9, 6:00 ET | vs Florida State Clemson, S.C. | ACCN |
| Sun May 10, 3:00 ET | vs Florida State Clemson, S.C. | ESPN2 |
| Tue May 12, 6:00 ET | at USC - Upstate Spartanburg, S.C. (Fifth Third Park) | ESPN+ |
| Thu May 14, 6:00 ET | at Virginia Tech Blacksburg, Va. | ACCNX |
| Fri May 15, 3:00 ET | at Virginia Tech Blacksburg, Va. | ACCNX |
| Sat May 16, 1:00 ET | at Virginia Tech Blacksburg, Va. | ACCNX |