| Date | Game | |
| Sat Sep 4, 7:30 ET | at Georgia Charlotte, N.C. | L 3-10 |
| Sat Sep 11, 5:00 ET | vs South Carolina State Clemson, S.C. | W 49-3 |
| Sat Sep 18, 3:30 ET | vs Georgia Tech Clemson, S.C. | W 14-8 |
| Sat Sep 25, 3:30 ET | at NC State Raleigh, N.C. | L 21-27 |
| Sat Oct 2, 7:30 ET | vs Boston College Clemson, S.C. | W 19-13 |
| Fri Oct 15, 7:00 ET | at Syracuse Syracuse, N.Y. | W 17-14 |
| Sat Oct 23, 3:30 ET | at Pitt Pittsburgh, Pa. | L 17-27 |
| Sat Oct 30, 3:30 ET | vs Florida State Clemson, S.C. | W 30-20 |
| Sat Nov 6, 7:30 ET | at Louisville Louisville, Ky. | W 30-24 |
| Sat Nov 13, 12:00 ET | vs UConn Clemson, S.C. | W 44-7 |
| Sat Nov 20, 12:00 ET | vs Wake Forest Clemson, S.C. | W 48-27 |
| Sat Nov 27 | at South Carolina Columbia, S.C. | W 30-0 |
| Wed Dec 29, 5:45 ET | vs Iowa State Cheez-It Bowl: Camping World Stadium, Orlando, FL | W 20-13 |