| Date | Game | |
| Mon Sep 5, 8:00 ET | at Georgia Tech Atlanta, Ga. | W 41-10 |
| Sat Sep 10, 3:30 ET | vs Furman Clemson, S.C. | W 35-12 |
| Sat Sep 17, 8:00 ET | vs Louisiana Tech Clemson, S.C. | W 48-20 |
| Sat Sep 24, 12:00 ET | at Wake Forest Winston-Salem, N.C. | W 51-45 |
| Sat Oct 1, 7:30 ET | vs NC State Clemson, S.C. | W 30-20 |
| Sat Oct 8, 7:30 ET | at Boston College Chestnut Hill, Mass. | W 31-3 |
| Sat Oct 15, 7:30 ET | at Florida State Tallahassee, Fla. | W 34-28 |
| Sat Oct 22, 12:00 ET | vs Syracuse Clemson, S.C. | W 27-21 |
| Sat Nov 5, 7:30 ET | at Notre Dame Notre Dame, Ind. | L 14-35 |
| Sat Nov 12 | vs Louisville Clemson, S.C. | W 31-16 |
| Sat Nov 19, 3:30 ET | vs Miami Clemson, S.C. | W 40-10 |
| Sat Nov 26, 12:00 ET | vs South Carolina Clemson, S.C. | L 30-31 |
| Sat Dec 3, 8:00 ET | vs North Carolina Charlotte, N.C. / Subway ACC Football Championship Game | W 39-10 |
| Fri Dec 30, 8:00 ET | vs Tennessee Miami, Fla. / Capital One Orange Bowl | L 14-31 |