| Date | Game | |
| Wed Nov 25, 8:30 ET | vs Mississippi State Eastern Florida State College, Melbourne, FL | W 53-42 |
| Thu Nov 26, 8:30 ET | vs Purdue Eastern Florida State College, Melbourne, FL | W 81-70 |
| Wed Dec 2, 6:00 ET | vs South Carolina State Littlejohn Coliseum, Clemson, SC | W 75-38 |
| Wed Dec 9, 5:00 ET | vs Maryland Littlejohn Coliseum, Clemson, SC | W 67-51 |
| Sat Dec 12, 8:00 ET | vs Alabama State Farm Arena, Atlanta, GA | W 64-56 |
| Tue Dec 15, 6:30 ET | at Virginia Tech Cassell Coliseum, Blacksburg, VA | L 60-66 |
| Sat Dec 19, 12:00 ET | at South Carolina Colonial Life Arena, Columbia, SC | SECN+ |
| Mon Dec 21, 12:00 ET | vs Morehead State Littlejohn Coliseum, Clemson, SC | W 66-51 |
| Tue Dec 29, 7:00 ET | vs Florida State Littlejohn Coliseum, Clemson, SC | W 77-67 |
| Sat Jan 2, 2:00 ET | at Miami Watsco Center, Coral Gables, FL | W 66-65 |
| Tue Jan 5, 7:00 ET | vs NC State Littlejohn Coliseum, Clemson, SC | W 74-70 |
| Sat Jan 16, 6:00 ET | vs Virginia Littlejohn Coliseum, Clemson, SC | L 50-85 |
| Wed Jan 20, 7:00 ET | at Georgia Tech McCamish Pavilion, Atlanta, GA | L 65-83 |
| Sat Jan 23, 3:00 ET | at Florida State Donald L. Tucker Civic Center, Tallahassee, FL | L 61-80 |
| Wed Jan 27, 9:00 ET | vs Louisville Littlejohn Coliseum, Clemson, SC | W 54-50 |
| Sat Jan 30, 12:00 ET | at Duke Cameron Indoor Stadium, Durham, NC | L 53-79 |
| Tue Feb 2, 7:00 ET | vs North Carolina Littlejohn Coliseum, Clemson, SC | W 63-50 |
| Sat Feb 6, 2:00 ET | vs Syracuse Littlejohn Coliseum, Clemson, SC | W 78-61 |
| Fri Feb 12, 8:00 ET | vs Georgia Tech Littlejohn Coliseum, Clemson, SC | W 74-72 |
| Wed Feb 24, 4:30 ET | at Wake Forest LJVM Coliseum, Winston-Salem, NC | W 60-39 |
| Sat Feb 27, 2:00 ET | vs Miami Littlejohn Coliseum, Clemson, SC | W 66-58 |
| Wed Mar 3, 5:00 ET | at Syracuse The Dome, Syracuse, NY | L 54-64 |
| Sat Mar 6, 12:00 ET | vs Pittsburgh Littlejohn Coliseum, Clemson, SC | W 77-62 |
| Wed Mar 10, 2:30 ET | vs Miami Greensboro, N.C. | L 64-67 |
| Fri Mar 19, 9:20 ET | vs Rutgers Bankers Life Fieldhouse, Indianapolis, IN | L 56-60 |