| Date | Game | |
| Tue Nov 9, 7:00 ET | vs Presbyterian Littlejohn Coliseum, Clemson, SC | W 64-53 |
| Fri Nov 12, 7:00 ET | vs Wofford Littlejohn Coliseum, Clemson, SC | W 76-68 |
| Mon Nov 15, 7:00 ET | vs Bryant Littlejohn Coliseum, Clemson, SC | W 93-70 |
| Thu Nov 18, 4:00 ET | vs Temple TD Arena, Charleston, SC | W 75-48 |
| Fri Nov 19, 2:30 ET | vs St. Bonaventure TD Arena, Charleston, SC | L 65-68 |
| Sun Nov 21 | vs TBD TD Arena, Charleston, SC | |
| Sun Nov 21, 5:00 ET | vs West Virginia TD Arena, Charleston, SC | L 59-66 |
| Fri Nov 26, 2:00 ET | vs Charleston Southern Littlejohn Coliseum, Clemson, SC | W 91-59 |
| Tue Nov 30, 9:00 ET | at Rutgers RAC, Piscataway, NJ | L 64-74 |
| Sat Dec 4, 12:00 ET | at Miami Watsco Center, Coral Gables, FL | L 75-80 |
| Sat Dec 11, 2:00 ET | vs Drake State Farm Arena, Atlanta, GA | W 90-80 |
| Tue Dec 14, 7:00 ET | vs Miami Littlejohn Coliseum, Clemson, SC | W 89-76 |
| Sat Dec 18, 6:00 ET | vs South Carolina Littlejohn Coliseum, Clemson, SC | W 70-56 |
| Wed Dec 22, 7:00 ET | at Virginia John Paul Jones Arena, Charlottesville, VA | W 67-50 |
| Tue Jan 4, 9:00 ET | vs Virginia Littlejohn Coliseum, Clemson, SC | L 65-75 |
| Sat Jan 8, 12:00 ET | at NC State PNC Arena, Raleigh, NC | W 70-65 |
| Wed Jan 12, 7:00 ET | at Notre Dame Purcell Pavilion, Notre Dame, IN | L 56-72 |
| Sat Jan 15, 6:30 ET | vs Boston College Littlejohn Coliseum, Clemson, SC | L 68-70 |
| Tue Jan 18, 9:00 ET | at Syracuse Carrier Dome, Syracuse, NY | L 78-91 |
| Sat Jan 22, 6:00 ET | vs Pittsburgh Littlejohn Coliseum, Clemson, SC | W 75-48 |
| Tue Jan 25, 7:00 ET | at Duke Cameron Indoor Stadium, Durham, NC | L 69-71 |
| Wed Feb 2, 7:00 ET | vs Florida State Littlejohn Coliseum, Clemson, SC | W 75-69 |
| Sat Feb 5, 2:00 ET | at Georgia Tech McCamish Pavilion, Atlanta, GA | L 64-69 |
| Tue Feb 8, 6:00 ET | vs North Carolina Littlejohn Coliseum, Clemson, SC | L 77-79 |
| Thu Feb 10, 8:00 ET | vs Duke Littlejohn Coliseum, Clemson, SC | L 64-82 |
| Sat Feb 12, 7:00 ET | vs Notre Dame Littlejohn Coliseum, Clemson, SC | L 61-76 |
| Tue Feb 15, 7:00 ET | at Florida State Donald L. Tucker Civic Center, Tallahassee, FL | L 80-81 |
| Sat Feb 19, 3:00 ET | at Louisville KFC Yum Center, Louisville, KY | L 61-70 |
| Wed Feb 23, 7:00 ET | vs Wake Forest Littlejohn Coliseum, Clemson, SC | W 80-69 |
| Sat Feb 26, 3:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | W 70-60 |
| Wed Mar 2, 7:00 ET | vs Georgia Tech Littlejohn Coliseum, Clemson, SC | W 68-65 |
| Sat Mar 5, 2:00 ET | vs Virginia Tech Littlejohn Coliseum, Clemson, SC | W 63-59 |
| Tue Mar 8, 4:30 ET | vs NC State Barclays Center, Brooklyn, NY | W 70-64 |
| Wed Mar 9, 7:00 ET | vs Virginia Tech Barclays Center, Brooklyn, NY | L 75-76 |