| Date | Game | |
| Mon Nov 3, 7:00 ET | vs New Hampshire Clemson, SC | ACCNX |
| Fri Nov 7, 7:00 ET | vs Gardner-Webb Clemson, SC | ACCN |
| Tue Nov 11, 7:00 ET | vs Morehead State Clemson, SC | ACCNX |
| Sat Nov 15, 12:00 ET | at Georgetown Washington, DC | Peacock |
| Mon Nov 17, 9:00 ET | vs North Alabama Clemson, SC | ACCNX |
| Fri Nov 21, 6:30 ET | vs West Virginia Charleston, SC | |
| Sun Nov 23 | vs Georgia/Xavier Charleston, SC | |
| Fri Nov 28, 7:00 ET | vs Alabama A&M Clemson, SC | |
| Wed Dec 3, 7:15 ET | at Alabama Tuscaloosa, Ala. | ESPNU |
| Tue Dec 9, 6:30 ET | vs BYU New York, NY | ESPN |
| Sat Dec 13, 3:00 ET | vs Mercer Clemson, SC | ACCNX |
| Tue Dec 16, 7:00 ET | vs South Carolina Clemson, SC | ESPN2 |
| Sun Dec 21, 3:00 ET | vs Cincinnati Greenville, SC | ESPN |
| Wed Dec 31, 2:00 ET | at Syracuse Syracuse, NY | ESPN2 |
| Sat Jan 3, 12:00 ET | at Pitt Pittsburgh | The CW |
| Tue Jan 6 | vs SMU Clemson, SC | |
| Tue Jan 13, 7:00 ET | vs Boston College Clemson, SC | |
| Sat Jan 17, 2:15 ET | vs Miami Clemson, SC | The CW |
| Tue Jan 20, 7:00 ET | vs NC State Clemson, SC | ACCN |
| Sat Jan 24, 12:00 ET | at Georgia Tech Atlanta, Ga. | ACCN |
| Sat Jan 31, 12:00 ET | vs Pitt | ACCN |
| Wed Feb 4, 10:00 ET | at Stanford Palo Alto, CA | ACCN |
| Sat Feb 7 | at California Berkeley, CA | |
| Wed Feb 11, 7:00 ET | vs Virginia Tech Clemson, SC | ACCN |
| Sat Feb 14, 12:00 ET | at Duke Durham, N.C. | ESPN |
| Wed Feb 18, 7:00 ET | at Wake Forest Winston-Salem, N.C. | ACCN |
| Sat Feb 21, 12:00 ET | vs Florida State Clemson, SC | The CW |
| Sat Feb 28 | vs Louisville Clemson, S.C. | ESPN/2 |
| Tue Mar 3, 7:00 ET | at North Carolina Chapel Hill | ESPN, ESPN2 or ESPNU |
| Sat Mar 7, 12:00 ET | vs Georgia Tech Clemson, SC | ACCN |