| Date | Game | |
| Sat Jan 15, 12:00 ET | vs Furman Clemson, S.C. | W 6-1 |
| Fri Jan 21, 5:00 ET | vs Wofford Clemson, S.C. | W 7-0 |
| Sun Jan 23, 12:00 ET | vs East Tennessee State Clemson, S.C. | W 6-1 |
| Sun Jan 30 | vs Miami Waco, TX | L 1-4 |
| Mon Jan 31 | vs William & Mary Clemson, SC | W 4-0 |
| Fri Feb 4, 5:00 ET | at South Carolina Columbia, SC | L 0-7 |
| Sun Feb 13, 12:00 ET | vs North Florida Clemson, S.C. | W 6-1 |
| Sat Feb 19, 12:00 ET | vs UNC Charlotte Clemson, S.C. | L 3-4 |
| Sat Feb 19, 5:00 ET | vs Coastal Carolina Clemson, S.C. | W 4-3 |
| Fri Mar 4, 5:00 ET | at Louisville LOUISVILLE, KY | L 2-4 |
| Sun Mar 6, 12:00 ET | at Notre Dame Notre Dame, Ind. | L 1-4 |
| Sat Mar 12, 12:00 ET | vs UNC Wilmington Clemson, S.C. | W 7-0 |
| Sat Mar 12, 5:00 ET | vs The Citadel Clemson, S.C. | W 7-0 |
| Fri Mar 18, 1:00 ET | vs Virginia Tech Clemson, S.C. | L 3-4 |
| Sun Mar 20, 12:00 ET | vs Virginia Clemson, S.C. | L 0-4 |
| Wed Mar 23, 4:00 ET | at Georgia Tech Atlanta, Ga. | L 2-5 |
| Sun Mar 27, 12:00 ET | vs Boston College Clemson, SC | W 7-0 |
| Sun Mar 27, 8:00 ET | vs Elon Clemson, SC | W 4-3 |
| Fri Apr 1, 4:30 ET | at North Carolina Chapel Hill, N.C. | L 0-7 |
| Sun Apr 3, 12:00 ET | at Duke Durham, N.C. | L 0-4 |
| Fri Apr 8, 4:00 ET | at Wake Forest Winston-Salem, N.C. | L 1-6 |
| Sun Apr 10, 12:00 ET | at NC State Raleigh, NC | L 2-5 |
| Thu Apr 14, 5:00 ET | vs Florida State Clemson, S.C. | W 4-3 |
| Sat Apr 16, 12:00 ET | vs Miami Clemson, S.C. | L 2-4 |
| Wed Apr 20, 10:00 AM ET | vs Boston College ACC Championship / Rome, Ga. | W 4-0 |
| Thu Apr 21, 10:00 AM ET | vs Duke ACC Championship / Rome, Ga. | W 4-3 |
| Fri Apr 22, 10:00 AM ET | vs Louisville ACC Championship / Rome, Ga. | L 1-4 |