| Date | Game | |
| Thu Feb 9, 5:30 ET | at FIU Miami, FL | W 10-1 |
| Fri Feb 10, 3:00 ET | vs Georgia State Miami, FL | W 11-2 |
| Sat Feb 11, 10:00 AM ET | vs Kansas City Miami, FL | W 8-1 |
| Sat Feb 11, 5:30 ET | vs Georgia State | W 11-3 |
| Sun Feb 12 | at FIU | W 4-0 |
| Tue Feb 14, 5:00 ET | at Furman University Greenville, SC | W 10-0 |
| Fri Feb 17, 3:00 ET | vs Northwestern Clemson, SC | W 15-2 |
| Sat Feb 18, 3:00 ET | vs Northwestern Clemson, SC | W 3-2 |
| Sat Feb 18, 5:29 ET | vs Ohio State Clemson, SC | W 5-1 |
| Sun Feb 19, 12:30 ET | vs Ohio State Clemson, SC | W 10-0 |
| Tue Feb 21, 4:00 ET | vs Georgia Clemson, SC | W 7-1 |
| Thu Feb 23, 6:00 ET | at USF Tampa, FL | W 6-0 |
| Fri Feb 24, 12:30 ET | vs UIC Tampa, FL | W 9-2 |
| Sat Feb 25, 9:00 AM ET | vs Michigan State Tampa, FL | W 4-1 |
| Sat Feb 25, 11:30 AM ET | vs Tennessee Tampa, FL | L 0-1 |
| Sun Feb 26, 9:00 AM ET | vs Michigan State Tampa, FL | W 8-0 |
| Wed Mar 1, 4:00 ET | vs Gardner-Webb Clemson, S.C. | W 8-0 |
| Wed Mar 1, 6:00 ET | vs Gardner-Webb Clemson, SC | W 4-1 |
| Sat Mar 4, 1:00 ET | vs Syracuse Clemson, SC | W 4-1 |
| Sat Mar 4, 1:00 ET | vs Syracuse Clemson, SC | W 4-1 |
| Sat Mar 4, 3:00 ET | vs Syracuse Clemson, SC | W 8-0 |
| Wed Mar 8, 3:00 ET | vs Mercer Clemson, SC | W 18-0 |
| Fri Mar 10, 3:00 ET | vs Bryant University Clemson, SC | W 10-1 |
| Fri Mar 10, 5:30 ET | vs UNC Greensboro Clemson, SC | W 3-0 |
| Sat Mar 11, 3:00 ET | vs Jacksonville University Clemson, SC | W 9-0 |
| Sat Mar 11, 5:30 ET | vs UNC Greensboro Clemson, SC | W 6-1 |
| Wed Mar 15 | vs Charlotte Clemson, SC | W 9-1 |
| Sat Mar 18, 1:00 ET | vs Virginia Clemson, SC | W 4-1 |
| Sat Mar 18, 3:00 ET | vs Virginia Clemson, SC | W 1-0 |
| Sun Mar 19, 12:00 ET | vs Virginia Clemson, SC | W 2-0 |
| Fri Mar 24, 6:00 ET | at Georgia Tech Atlanta, GA | W 9-1 |
| Sat Mar 25, 3:00 ET | at Georgia Tech Atlanta, GA | W 8-4 |
| Sun Mar 26, 1:00 ET | at Georgia Tech Atlanta, GA | W 13-0 |
| Tue Mar 28 | vs University of South Carolina Clemson, SC | W 10-0 |
| Fri Mar 31, 12:00 ET | at Boston College Chestnut Hill, MA | W 8-4 |
| Fri Mar 31, 3:10 ET | at Boston College Chestnut Hill, MA | W 7-3 |
| Sun Apr 2, 12:00 ET | at Boston College Chestnut Hill, MA | W 8-0 |
| Wed Apr 5 | vs Furman University Clemson, SC | W 4-1 |
| Thu Apr 6 | vs Florida State Clemson, SC | L 0-7 |
| Fri Apr 7 | vs Florida State Clemson, SC | L 1-4 |
| Sat Apr 8 | vs Florida State Clemson, SC | L 2-3 |
| Tue Apr 11 | at University of South Carolina Columbia, SC | W 4-3 |
| Fri Apr 14, 2:00 ET | at NC State Raleigh, N.C. | W 4-1 |
| Sat Apr 15, 2:00 ET | at NC State Raleigh, N.C. | W 6-3 |
| Sun Apr 16, 4:00 ET | at NC State Raleigh, N.C. | L 5-7 |
| Tue Apr 18 | vs Winthrop University Clemson, SC | W 2-0 |
| Fri Apr 21, 6:00 ET | vs Pitt Clemson, SC | W 3-2 |
| Sat Apr 22, 12:00 ET | vs Pitt Clemson, SC | W 2-0 |
| Sun Apr 23, 12:00 ET | vs Pitt Clemson, SC | W 11-2 |
| Wed Apr 26 | vs Liberty University Clemson, SC | L 4-5 |
| Fri Apr 28, 4:00 ET | at Virginia Tech Blacksburg, VA | L 4-5 |
| Sat Apr 29, 4:00 ET | at Virginia Tech Blacksburg, VA | L 1-3 |
| Sun Apr 30, 2:00 ET | at Virginia Tech Blacksburg, VA | W 5-4 |
| Thu May 11, 7:30 ET | vs North Carolina South Bend, IN / ACC Championship | W 2-1 |
| Fri May 12 | vs Duke University | L 0-2 |
| Fri May 19, 3:00 ET | vs UNC Greensboro Clemson, SC / NCAA Regional | W 17-2 |
| Sat May 20, 1:00 ET | vs Auburn Clemson, SC | W 7-0 |
| Sun May 21, 12:00 ET | vs Auburn Clemson, SC / NCAA Regional | L 2-5 |
| Sun May 21, 3:00 ET | vs Auburn University Clemson, SC | W 5-1 |
| Fri May 26, 2:00 ET | at Oklahoma Norman, OK / NCAA Super Regional | L 2-9 |
| Sat May 27, 1:00 ET | at Oklahoma Norman, OK / NCAA Super Regional | L 7-8 |