| Date | Game | |
| Thu Feb 6, 11:00 AM ET | vs Ole Miss Boca Raton, FL | L 2-3 |
| Thu Feb 6, 2:00 ET | vs Kansas Boca Raton, FL | W 4-3 |
| Fri Feb 7, 6:00 ET | at Florida Atlantic Boca Raton, FL | L 2-6 |
| Sat Feb 8, 11:15 AM ET | vs Georgia State Boca Raton, FL | W 10-1 |
| Sun Feb 9, 11:30 AM ET | vs Missouri State Boca Raton, FL | W 13-0 |
| Thu Feb 13, 1:00 ET | vs Missouri Clearwater, FL | L 6-10 |
| Thu Feb 13, 3:00 ET | vs Auburn Clearwater, FL | L 3-6 |
| Fri Feb 14, 1:00 ET | vs Kentucky Clearwater, FL | L 6-7 |
| Sat Feb 15, 9:00 AM ET | vs UCF Clearwater, FL | L 4-6 |
| Sun Feb 16, 10:00 AM ET | vs Ohio State Clearwater, FL | W 11-3 |
| Tue Feb 18, 6:00 ET | vs Charlotte Clemson, SC | W 14-8 |
| Fri Feb 21, 12:30 ET | vs Elon Clemson, SC | W 4-3 |
| Fri Feb 21, 3:00 ET | vs Villanova Clemson, SC | W 1-0 |
| Sat Feb 22, 3:00 ET | vs Marshall Clemson, SC | W 8-3 |
| Sun Feb 23 | vs Marshall University Clemson, SC | W 8-0 |
| Wed Feb 26, 4:00 ET | vs Georgia Clemson, SC | W 5-3 |
| Fri Feb 28, 12:30 ET | vs Lafayette Clemson, SC | W 11-3 |
| Fri Feb 28, 3:00 ET | vs East Carolina Clemson, SC | W 6-2 |
| Sat Mar 1, 3:00 ET | vs Indiana Clemson, SC | W 11-5 |
| Sun Mar 2 | vs Indiana University Clemson, SC | W 8-0 |
| Tue Mar 4, 6:00 ET | vs Furman Clemson, SC | W 12-0 |
| Wed Mar 5, 3:00 ET | vs Charleston Southern Clemson, SC | W 7-0 |
| Wed Mar 5, 5:00 ET | vs Charleston Southern Clemson, SC | W 12-0 |
| Fri Mar 7, 6:00 ET | vs Duke Clemson, S.C. | W 12-4 |
| Sat Mar 8, 1:00 ET | vs Duke Clemson, S.C. | L 3-5 |
| Sun Mar 9, 12:00 ET | vs Duke Clemson, S.C. | L 1-2 |
| Fri Mar 14, 6:00 ET | vs North Carolina Clemson, SC | W 4-1 |
| Sat Mar 15, 1:00 ET | vs North Carolina Clemson, SC | L 3-6 |
| Sun Mar 16, 1:00 ET | vs North Carolina Clemson, SC | W 10-2 |
| Wed Mar 19, 3:00 ET | at Fordham New York, NY | W 14-1 |
| Fri Mar 21, 3:00 ET | at Syracuse Syracuse, N.Y. | W 8-1 |
| Sat Mar 22, 1:00 ET | at Syracuse Syracuse, N.Y. | W 10-0 |
| Sun Mar 23, 2:00 ET | at Syracuse Syracuse, N.Y. | W 15-0 |
| Tue Mar 25, 6:00 ET | at South Carolina Columbia, SC | L 0-6 |
| Fri Mar 28, 6:00 ET | vs California Clemson, SC | W 5-3 |
| Sat Mar 29, 2:30 ET | vs California Clemson, SC | W 2-1 |
| Sat Mar 29, 6:00 ET | vs California Clemson, SC | W 14-4 |
| Tue Apr 1, 6:00 ET | vs Gardner-Webb Clemson, SC | W 11-3 |
| Fri Apr 4, 9:00 ET | at Stanford Stanford, CA | W 7-5 |
| Sat Apr 5, 5:00 ET | at Stanford Stanford, CA | L 1-11 |
| Sun Apr 6, 3:00 ET | at Stanford Stanford, CA | W 7-6 |
| Wed Apr 9, 6:00 ET | vs Winthrop Clemson, SC | W 4-1 |
| Fri Apr 11, 8:00 ET | at NC State Raleigh, NC | W 17-3 |
| Sat Apr 12, 5:00 ET | at NC State Raleigh, NC | W 8-7 |
| Sun Apr 13, 1:00 ET | at NC State Raleigh, NC | W 8-3 |
| Tue Apr 15, 7:00 ET | vs South Carolina Clemson, SC | W 2-1 |
| Thu Apr 17, 6:00 ET | vs Boston College Clemson, SC | W 6-2 |
| Fri Apr 18, 6:00 ET | vs Boston College Clemson, SC | W 8-4 |
| Sat Apr 19, 12:00 ET | vs Boston College Clemson, SC | L 2-5 |
| Tue Apr 22, 6:00 ET | at Tennessee Knoxville, TN | W 4-3 |
| Fri Apr 25, 6:00 ET | at Georgia Tech Atlanta, GA | W 6-2 |
| Sat Apr 26, 7:00 ET | at Georgia Tech Atlanta, GA | W 19-0 |
| Sun Apr 27, 12:00 ET | at Georgia Tech Atlanta, GA | W 8-2 |
| Thu May 8, 5:00 ET | vs Virginia Brighton, MA | W 7-4 |
| Fri May 9, 12:30 ET | vs Virginia Tech Brighton, MA | W 10-9 |
| Sat May 10, 3:00 ET | vs Florida State Brighton, MA | W 2-1 |
| Fri May 16, 4:30 ET | vs USC - Upstate Clemson, SC | W 10-2 |
| Sat May 17, 1:30 ET | vs Northwestern Clemson, SC | W 1-0 |
| Sun May 18, 1:00 ET | vs Kentucky Clemson, SC | W 5-1 |
| Thu May 22, 9:00 ET | vs Texas Austin, TX | W 7-4 |
| Fri May 23, 9:00 ET | vs Texas Austin, TX | L 5-7 |
| Sat May 24, 9:00 ET | vs Texas Austin, TX | L 5-6 |