| Date | Game | |
| Thu Feb 5, 7:00 ET | vs Southeastern Louisiana Clearwater, FL | W 5-3 |
| Fri Feb 6, 4:00 ET | vs Oregon Clearwater, FL | W 6-5 |
| Fri Feb 6, 7:00 ET | vs Liberty Clearwater, FL | W 9-4 |
| Sat Feb 7, 4:00 ET | vs Auburn Clearwater, FL | L 5-10 |
| Sun Feb 8, 10:00 AM ET | vs Michigan State Clearwater, FL | L 2-5 |
| Tue Feb 10, 6:00 ET | vs Furman Clemson, SC | W 9-1 |
| Thu Feb 12, 6:00 ET | vs Texas State San Marcos, TX | L 0-4 |
| Fri Feb 13, 5:45 ET | vs Arkansas San Marcos, TX | L 0-12 |
| Fri Feb 13, 8:00 ET | vs BYU San Marcos, TX | W 7-0 |
| Sun Feb 15, 10:00 AM ET | vs Wichita State San Marcos, TX | |
| Sun Feb 15, 11:00 AM ET | vs Arkansas San Marcos, TX | |
| Wed Feb 18, 5:00 ET | at Charlotte Charlotte, NC | |
| Fri Feb 20, 12:30 ET | vs Lipscomb Clemson, SC | |
| Fri Feb 20, 3:00 ET | vs Coastal Carolina Clemson, SC | |
| Sat Feb 21, 3:00 ET | vs Baylor Clemson, SC | |
| Sun Feb 22, 12:30 ET | vs TBD Clemson, SC | |
| Wed Feb 25 | at Georgia Athens, GA | |
| Fri Feb 27, 12:30 ET | vs Wofford Clemson, SC | |
| Fri Feb 27, 3:00 ET | vs Georgia Southern Clemson, SC | |
| Sat Feb 28, 3:00 ET | vs Mississippi State Clemson, SC | |
| Sun Mar 1, 12:30 ET | vs TBD Clemson, SC | |
| Wed Mar 4, 6:00 ET | vs College of Charleston Clemson, SC | |
| Fri Mar 6, 5:00 ET | vs Georgia Tech Clemson, SC | |
| Fri Mar 6, 6:00 ET | vs Georgia Tech Clemson, SC | |
| Sat Mar 7, 1:00 ET | vs Georgia Tech Clemson, SC | |
| Sat Mar 7, 3:00 ET | vs Georgia Tech Clemson, SC | |
| Sun Mar 8, 1:00 ET | vs Georgia Tech Clemson, SC | |
| Sun Mar 8, 6:00 ET | vs Georgia Tech Clemson, SC | |
| Tue Mar 10, 6:00 ET | vs Winthrop Clemson, SC | |
| Fri Mar 13, 5:00 ET | vs Louisville Clemson, SC | |
| Sat Mar 14, 1:00 ET | vs Louisville Clemson, SC | |
| Sun Mar 15, 12:00 ET | vs Louisville Clemson, SC | |
| Tue Mar 17, 5:00 ET | at Western Carolina Cullowhee, NC | |
| Fri Mar 20, 6:00 ET | at Notre Dame South Bend, IN | |
| Sat Mar 21, 1:00 ET | at Notre Dame South Bend, IN | |
| Sun Mar 22, 12:00 ET | at Notre Dame South Bend, IN | |
| Wed Mar 25, 7:00 ET | at South Carolina Columbia, SC | |
| Fri Mar 27, 6:00 ET | vs Florida State Clemson, SC | |
| Sat Mar 28, 12:00 ET | vs Florida State Clemson, SC | |
| Sun Mar 29, 6:00 ET | vs Florida State Clemson, SC | |
| Tue Mar 31, 6:00 ET | vs Gardner-Webb Clemson, SC | |
| Thu Apr 2, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Thu Apr 2, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Fri Apr 3, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Fri Apr 3, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Sat Apr 4, 2:00 ET | at Virginia Tech Blacksburg, VA | |
| Sat Apr 4, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Fri Apr 10, 6:00 ET | at Pitt Pittsburgh, PA | |
| Sat Apr 11, 7:00 ET | at Pitt Pittsburgh, PA | |
| Sun Apr 12, 1:00 ET | at Pitt Pittsburgh, PA | |
| Tue Apr 14, 6:00 ET | vs South Carolina Clemson, SC | |
| Fri Apr 17, 6:00 ET | vs Virginia Clemson, SC | |
| Fri Apr 17, 6:00 ET | vs Virginia Clemson, SC | |
| Sat Apr 18, 1:00 ET | vs Virginia Clemson, SC | |
| Sat Apr 18, 1:00 ET | vs Virginia Clemson, SC | |
| Sun Apr 19, 12:00 ET | vs Virginia Clemson, SC | |
| Sun Apr 19, 12:00 ET | vs Virginia Clemson, SC | |
| Tue Apr 21, 6:00 ET | vs Presbyterian Clemson, SC | |
| Fri Apr 24, 6:00 ET | at Duke Durham, NC | |
| Sat Apr 25, 12:00 ET | at Duke Durham, NC | |
| Sun Apr 26, 5:00 ET | at Duke Durham, NC | |