| Date | Game | |
| Mon Nov 3, 11:00 AM ET | vs USC Upstate Clemson, SC | W 76-38 |
| Thu Nov 6, 7:00 ET | at Mercer Macon, Ga. | W 72-51 |
| Tue Nov 11, 6:00 ET | at South Carolina Columbia, SC | L 37-65 |
| Thu Nov 13, 7:00 ET | vs American Clemson, SC | W 78-38 |
| Sun Nov 16, 3:00 ET | vs Louisville Clemson, SC | L 54-65 |
| Sun Nov 23, 2:00 ET | at Furman Greenville, SC | W 76-58 |
| Fri Nov 28, 4:00 ET | vs Western Carolina Nassau, Bahamas | W 77-44 |
| Sun Nov 30, 6:30 ET | vs Michigan State Nassau, Bahamas | L 64-72 |
| Thu Dec 4, 7:00 ET | at Alabama Tuscaloosa, AL | ESPNU |
| Sun Dec 7, 2:00 ET | vs App State Clemson, SC | |
| Sun Dec 14, 2:00 ET | vs Pitt Clemson, SC | |
| Wed Dec 17, 11:00 AM ET | at Charleston Southern Charleston, SC | ESPN+ |
| Sun Dec 21, 2:00 ET | vs North Florida Clemson, SC | |
| Sun Dec 28, 3:00 ET | at Chicago State Chicago, IL | |
| Thu Jan 1, 7:00 ET | at Virginia Charlottesville, VA | |
| Sun Jan 4, 2:00 ET | at Miami Coral Gables, FL | |
| Thu Jan 8, 8:00 ET | vs NC State Clemson, SC | ACCN |
| Sun Jan 11, 4:00 ET | at Georgia Tech Atlanta, Ga. | |
| Sun Jan 18, 12:00 ET | vs Wake Forest Clemson, SC | |
| Thu Jan 22, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Sun Jan 25, 3:00 ET | at Notre Dame South Bend, Ind. | |
| Thu Jan 29, 7:00 ET | vs SMU | |
| Sun Feb 1, 6:00 ET | vs Florida State Clemson, SC | |
| Thu Feb 5, 6:00 ET | at North Carolina Chapel Hill, N.C. | |
| Sun Feb 8, 2:00 ET | vs Boston College Clemson, S.C. | |
| Thu Feb 12, 9:00 ET | vs Georgia Tech Clemson, SC | |
| Sun Feb 15, 2:00 ET | at Syracuse Syracuse, NY | |
| Sun Feb 22, 2:00 ET | vs Duke Clemson, SC | |
| Thu Feb 26, 10:00 ET | at California Berkeley, CA | |
| Sun Mar 1, 2:00 ET | at Stanford Stanford, CA | |