| Date | Game | |
| Mon Nov 2 | vs Radford Clemson, SC | |
| Thu Nov 5 | vs ETSU Clemson, SC | |
| Sun Nov 8 | vs UNCG Clemson, SC | |
| Thu Nov 12 | vs South Carolina Clemson, SC | |
| Sun Nov 15 | vs Stetson Clemson, SC | ACCNX |
| Wed Nov 18 | vs USC Upstate Clemson, SC | ACCNX |
| Fri Nov 20 | vs UNC Asheville Clemson, SC | ACCNX |
| Thu Nov 26, 11:00 AM ET | vs Robert Morris Daytona, Fla. | BallerTV |
| Fri Nov 27, 1:15 ET | vs Georgetown Daytona, Fla. | BallerTV |
| Sun Nov 29 | vs Elon Clemson, SC | ACCNX |
| Thu Dec 3 | at Kentucky Lexington, KY | |
| Sun Dec 6 | vs Gardner-Webb Clemson, SC | ACCNX |
| Sun Dec 13, 2:00 ET | at Wake Forest Winston-Salem, N.C. | |
| Tue Dec 15, 11:00 AM ET | vs Western Carolina Clemson, SC | ACCNX |
| Sun Dec 20 | at Louisville Louisville, KY | |
| Mon Dec 28 | vs Kennesaw State Clemson, SC | ACCNX |
| Thu Dec 31 | vs Stanford Clemson, SC | |
| Sun Jan 3 | vs North Carolina Clemson, SC | |
| Thu Jan 7 | at Georgia Tech Atlanta, GA | |
| Thu Jan 14 | at SMU Dallas, Texas | TBA |
| Sun Jan 17 | vs Virginia Clemson, SC | |
| Thu Jan 21 | vs Miami Clemson, SC | |
| Sun Jan 24 | at Duke Durham, N.C. | |
| Thu Jan 28 | at Pitt Pittsburgh, Pa. | |
| Thu Feb 4 | vs Virginia Tech Clemson, SC | |
| Sun Feb 7 | vs Notre Dame Clemson, SC | |
| Thu Feb 11, 6:00 ET | at Florida State Tallahassee, Fla. | |
| Sun Feb 14 | at Boston College Chestnut Hill, Mass. | |
| Thu Feb 18 | vs California Clemson, SC | |
| Mon Feb 22 | vs Syracuse Clemson, SC | |
| Thu Feb 25 | vs Georgia Tech Clemson, SC | |
| Sun Feb 28 | at NC State Raleigh, N.C. | |