| Date | Game | |
| Mon Nov 2, 12:00 ET | vs Radford Clemson, SC | |
| Thu Nov 5, 7:00 ET | vs ETSU Clemson, SC | |
| Sun Nov 8, 2:00 ET | vs UNCG Clemson, SC | |
| Thu Nov 12, 7:00 ET | vs South Carolina Clemson, SC | |
| Sun Nov 15, 5:00 ET | vs Stetson Clemson, SC | ACCNX |
| Wed Nov 18, 6:00 ET | vs USC Upstate Clemson, SC | ACCNX |
| Fri Nov 20, 5:00 ET | vs UNC Asheville Clemson, SC | ACCNX |
| Thu Nov 26, 11:00 AM ET | vs Robert Morris Daytona, Fla. | BallerTV |
| Fri Nov 27, 1:15 ET | vs Georgetown Daytona, Fla. | BallerTV |
| Sun Nov 29, 2:00 ET | vs Elon Clemson, SC | ACCNX |
| Thu Dec 3, 7:00 ET | at Kentucky Lexington, KY | |
| Sun Dec 6, 6:00 ET | vs Gardner-Webb Clemson, SC | ACCNX |
| Sun Dec 13, 2:00 ET | at Wake Forest Winston-Salem, N.C. | |
| Tue Dec 15, 11:00 AM ET | vs Western Carolina Clemson, SC | ACCNX |
| Sun Dec 20, 5:30 ET | at Louisville Louisville, KY | |
| Mon Dec 28, 7:00 ET | vs Kennesaw State Clemson, SC | ACCNX |
| Thu Dec 31, 7:00 ET | vs Stanford Clemson, SC | |
| Sun Jan 3, 2:00 ET | vs North Carolina Clemson, SC | |
| Thu Jan 7, 7:00 ET | at Georgia Tech Atlanta, GA | |
| Thu Jan 14, 7:00 ET | at SMU Dallas, Texas | TBA |
| Sun Jan 17, 2:00 ET | vs Virginia Clemson, SC | |
| Thu Jan 21, 7:00 ET | vs Miami Clemson, SC | |
| Sun Jan 24, 12:00 ET | at Duke Durham, N.C. | |
| Thu Jan 28, 6:00 ET | at Pitt Pittsburgh, Pa. | |
| Thu Feb 4, 6:00 ET | vs Virginia Tech Clemson, SC | |
| Sun Feb 7, 12:00 ET | vs Notre Dame Clemson, SC | |
| Thu Feb 11, 6:00 ET | at Florida State Tallahassee, Fla. | |
| Sun Feb 14, 12:00 ET | at Boston College Chestnut Hill, Mass. | |
| Thu Feb 18, 8:00 ET | vs California Clemson, SC | |
| Mon Feb 22, 6:00 ET | vs Syracuse Clemson, SC | |
| Thu Feb 25, 7:00 ET | vs Georgia Tech Clemson, SC | |
| Sun Feb 28, 12:00 ET | at NC State Raleigh, N.C. | |