| Date | Game | |
| Sat Feb 11, 2:30 ET | vs Wofford Clemson, SC | W 23-1 |
| Wed Feb 15, 4:00 ET | vs Furman Clemson, SC | W 19-3 |
| Sat Feb 18, 1:00 ET | at Winthrop Rock Hill, SC | W 21-1 |
| Wed Feb 22, 4:00 ET | vs Gardner-Webb Clemson, SC | W 22-2 |
| Sat Feb 25, 1:00 ET | at Notre Dame South Bend, IN | L 9-12 |
| Fri Mar 3, 5:00 ET | at Virginia Charlottesville, VA | L 7-16 |
| Sun Mar 5, 12:00 ET | at Longwood Farmville, VA | W 21-3 |
| Wed Mar 8, 4:00 ET | vs Campbell Clemson, SC | W 18-7 |
| Sat Mar 11, 12:00 ET | vs Duke Clemson, SC | W 11-10 |
| Thu Mar 16, 4:00 ET | vs Boston College Clemson, SC | L 10-17 |
| Sun Mar 19, 1:00 ET | vs Radford Clemson, SC | W 23-2 |
| Wed Mar 22, 4:00 ET | vs Presbyterian Clemson, SC | W 20-4 |
| Sun Mar 26, 2:00 ET | at North Carolina Chapel Hill, N.C. | L 8-17 |
| Sat Apr 1, 1:00 ET | vs Louisville Clemson, SC | W 19-8 |
| Sat Apr 8, 2:00 ET | at Syracuse Syracuse, NY | L 10-19 |
| Sat Apr 15, 12:00 ET | at Virginia Tech Blacksburg, Va. | W 16-12 |
| Thu Apr 20, 5:00 ET | vs Pitt Clemson, SC | W 17-7 |
| Wed Apr 26, 8:00 ET | vs North Carolina Charlotte, NC | L 6-16 |