| Date | Game | |
| Sat Feb 10, 2:00 ET | vs Davidson Clemson, SC | W 19-10 |
| Wed Feb 14, 6:00 ET | at Furman Greenville, SC | W 11-5 |
| Sat Feb 17, 12:00 ET | vs Coastal Carolina Clemson, SC | W 16-5 |
| Sat Feb 24, 12:00 ET | at Duke Durham, N.C. | W 20-11 |
| Sat Mar 2, 1:00 ET | vs Virginia Clemson, SC | L 12-18 |
| Tue Mar 5, 2:00 ET | at Mercer Macon, GA | W 22-10 |
| Sat Mar 9, 3:00 ET | vs North Carolina Clemson, SC | L 9-18 |
| Mon Mar 11, 4:00 ET | vs Mercer Macon, GA | ACCNX |
| Mon Mar 11, 4:00 ET | at Wofford College Spartanburg, SC | W 23-4 |
| Sat Mar 16, 2:00 ET | at Louisville Louisville, KY | L 12-13 |
| Fri Mar 22, 7:00 ET | vs Notre Dame Clemson, SC | L 13-14 |
| Sun Mar 24, 1:00 ET | vs Queens Clemson, SC | W 21-4 |
| Sat Mar 30, 12:00 ET | vs Virginia Tech Clemson, S.C. | W 15-4 |
| Tue Apr 2, 5:00 ET | at East Carolina Greenville, NC | W 17-7 |
| Sun Apr 7, 12:00 ET | at Boston College Chestnut Hill, MA | L 4-16 |
| Sat Apr 13, 12:00 ET | vs Syracuse Clemson, SC | L 6-15 |
| Thu Apr 18, 4:00 ET | at Pitt Pittsburgh, PA | W 12-11 |
| Sun Apr 21, 2:00 ET | vs Pitt Clemson, SC | W 18-15 |
| Wed Apr 24, 5:00 ET | vs Notre Dame Charlotte, NC | L 12-14 |