| Date | Game | |
| Sat Feb 8, 5:00 ET | at Davidson Davidson, NC | W 14-6 |
| Wed Feb 12, 1:00 ET | at Vanderbilt Nashville, TN | W 20-12 |
| Sun Feb 16, 12:00 ET | vs Stetson Clemson, SC | W 26-6 |
| Sat Feb 22, 8:00 ET | at Notre Dame South Bend, Ind. | W 12-11 |
| Sat Mar 1, 12:00 ET | at Syracuse Syracuse, N.Y. | W 9-8 |
| Tue Mar 4, 4:00 ET | vs Queens Clemson, SC | W 25-5 |
| Sat Mar 8, 12:00 ET | vs Duke Clemson, S.C. | L 11-12 |
| Tue Mar 11, 3:00 ET | vs Mercer Clemson, SC | L 10-11 |
| Sat Mar 15, 12:00 ET | at North Carolina Chapel Hill, N.C. | L 5-18 |
| Thu Mar 20, 12:00 ET | vs Florida Clemson, SC | L 10-16 |
| Sun Mar 23, 12:00 ET | vs Louisville Clemson, S.C. | W 14-2 |
| Wed Mar 26, 6:00 ET | vs Albany Clemson, SC | W 21-8 |
| Sat Mar 29, 12:00 ET | vs California Clemson, SC | W 19-3 |
| Tue Apr 1, 5:00 ET | vs East Carolina Clemson, SC | W 15-4 |
| Sat Apr 5, 12:00 ET | at Virginia Tech Blacksburg, Va. | W 18-6 |
| Thu Apr 10, 6:00 ET | at Stanford Stanford, CA | L 8-14 |
| Thu Apr 17, 5:00 ET | vs Pitt Clemson, SC | W 14-6 |
| Wed Apr 23, 2:00 ET | vs Duke Charlotte, NC | W 15-7 |
| Fri Apr 25, 5:00 ET | vs North Carolina Charlotte, NC | L 7-17 |
| Fri May 9, 5:00 ET | vs Navy Chapel Hill, NC | W 11-8 |
| Sun May 11, 12:00 ET | at North Carolina Chapel Hill, NC | L 9-18 |