| Date | Game | |
| Wed Aug 12, 7:00 ET | at Auburn Auburn, AL | T 0-0 |
| Sun Aug 16, 12:00 ET | vs Ohio State Clemson, SC | T 0-0 |
| Thu Aug 20, 7:00 ET | at South Carolina Columbia, SC | L 0-1 |
| Sun Aug 23, 1:00 ET | vs Campbell Clemson, SC | W 5-0 |
| Thu Aug 27, 8:00 ET | at Arkansas Fayetteville, AR | W 1-0 |
| Thu Sep 3, 7:00 ET | vs Gardner-Webb Clemson, SC | W 5-1 |
| Sun Sep 6, 6:00 ET | vs UNC Asheville Clemson, SC | W 3-0 |
| Fri Sep 11, 8:00 ET | at Notre Dame South Bend, Ind. | |
| Thu Sep 17, 7:00 ET | vs Syracuse Clemson, SC | |
| Thu Sep 24, 7:00 ET | at Miami Coral Gables, FL | |
| Sun Sep 27, 1:00 ET | vs Boston College Clemson, SC | |
| Sun Oct 4, 3:30 ET | vs Florida State Clemson, SC | |
| Sat Oct 10, 6:00 ET | vs Louisville Clemson, SC | |
| Thu Oct 15, 8:00 ET | vs North Carolina Clemson, SC | |
| Thu Oct 22, 7:00 ET | at Virginia Charlottesville, VA | |
| Sun Oct 25, 5:00 ET | at Virginia Tech Blacksburg, VA | |
| Sun Oct 25, 5:00 ET | at Virginia Tech Blacksburg, VA | |
| Thu Nov 5, 7:00 ET | at Wake Forest Winston-Salem, NC | |