| Date | Game | |
| Fri Aug 29, 2:00 ET | vs Campbell Columbia, SC | |
| Sat Aug 30, 7:00 ET | vs East Tennessee State Columbia, SC | |
| Sun Aug 31, 3:00 ET | at South Carolina | SEC+ |
| Thu Sep 4, 6:00 ET | vs North Carolina A&T Clemson, SC | |
| Fri Sep 5, 6:00 ET | vs North Carolina A&T Clemson, SC | |
| Tue Sep 9, 6:00 ET | vs Georgia Clemson, SC | |
| Thu Sep 11, 6:00 ET | vs Elon Clemson, SC | |
| Fri Sep 12, 6:00 ET | vs USC - Upstate Clemson, SC | |
| Sat Sep 13, 4:00 ET | vs Wofford Clemson, SC | |
| Thu Sep 18, 7:00 ET | vs Georgetown Columbia, SC | |
| Fri Sep 19, 11:00 AM ET | vs Norfolk State Clemson, SC | |
| Fri Sep 19, 7:00 ET | vs Charleston Southern Clemson, SC | |
| Sun Sep 28, 1:00 ET | vs Miami Clemson, SC | |
| Fri Oct 24, 6:00 ET | vs Stanford Clemson, SC | |
| Sun Oct 26, 1:00 ET | vs California Clemson, SC | |
| Fri Oct 31, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Sun Nov 2, 1:00 ET | at Virginia Charlottesville, VA | |
| Sun Nov 9, 1:00 ET | at Boston College Chesnut Hill, MA | |
| Wed Nov 12, 7:00 ET | vs Georgia Tech Clemson, SC | |
| Fri Nov 14, 7:00 ET | at Georgia Tech Atlanta, GA | |
| Fri Nov 21, 6:00 ET | vs Notre Dame Clemson, SC | |
| Tue Nov 25 | vs Syracuse Clemson, SC | |