| Date | Game | |
| Fri Aug 28, 6:00 ET | vs Charleston Southern Clemson, SC | W 3-1 |
| Sat Aug 29, 5:00 ET | vs Butler Clemson, SC | L 2-3 |
| Sun Aug 30, 4:00 ET | vs Western Carolina Clemson, SC | W 3-1 |
| Fri Sep 4, 6:00 ET | vs UNC Greensboro Clemson, SC | W 3-1 |
| Sat Sep 5, 5:00 ET | vs East Carolina Clemson, SC | W 3-1 |
| Sun Sep 6, 4:00 ET | vs App State Clemson, SC | W 3-2 |
| Tue Sep 8, 6:00 ET | at Ole Miss | SECN+ |
| Fri Sep 11, 7:00 ET | vs South Carolina | ACCNX |
| Sun Sep 13, 3:00 ET | at Wofford | ESPN+ |
| Thu Sep 17, 6:00 ET | vs Furman | ACCNX |
| Fri Sep 18, 6:00 ET | vs New Hampshire Clemson, SC | |
| Sun Sep 20, 3:00 ET | vs USC Upstate Clemson, SC | |
| Fri Sep 25, 6:00 ET | vs Virginia Clemson, SC | |
| Sun Sep 27, 1:00 ET | vs Virginia Tech Clemson, SC | |
| Fri Oct 2, 7:00 ET | at North Carolina Chapel Hill, NC | |
| Sun Oct 4, 1:00 ET | at Duke Durham, NC | |
| Fri Oct 9, 7:00 ET | at Miami Coral Gables, FL | |
| Sun Oct 11, 1:00 ET | at Florida State Tallahassee, FL | |
| Fri Oct 16, 6:00 ET | vs Boston College Clemson, SC | |
| Sun Oct 18, 1:00 ET | vs Syracuse Clemson, SC | |
| Fri Oct 23, 6:00 ET | vs SMU Clemson, SC | |
| Sun Oct 25, 1:00 ET | vs Pitt Clemson, SC | |
| Fri Oct 30, 7:00 ET | at Louisville Louisville, KY | |
| Sun Nov 1, 1:00 ET | at Notre Dame South Bend, IN | |
| Fri Nov 6, 6:00 ET | vs Wake Forest Clemson, SC | |
| Sun Nov 8, 1:00 ET | vs NC State Clemson, SC | |
| Fri Nov 13, 10:00 ET | at Stanford Stanford, CA | |
| Sun Nov 15, 4:00 ET | at California Berkeley, CA | |
| Wed Nov 18, 7:00 ET | at Georgia Tech Atlanta, GA | |
| Fri Nov 20, 6:00 ET | vs Georgia Tech Clemson, SC | |
| Tue Nov 24, 2:00 ET | vs Florida State Clemson, SC | |
| Fri Nov 27, 3:00 ET | at Wake Forest Winston-Salem, NC | |