| Date | Game | |
| Fri Feb 17, 4:00 ET | vs St. Josephs Durham, N.C. | W 16-0 |
| Sat Feb 18, 3:00 ET | vs St. Josephs Durham, N.C. | W 2-1 |
| Sun Feb 19, 1:00 ET | vs St. Josephs Durham, N.C. | L 4-5 |
| Wed Feb 22, 4:00 ET | vs Liberty Durham, N.C. | L 6-8 |
| Fri Feb 24, 4:00 ET | vs Baylor Durham, N.C. | W 20-1 |
| Sat Feb 25, 5:00 ET | vs Baylor Durham, N.C. | W 22-3 |
| Sun Feb 26, 12:00 ET | vs Baylor Durham, N.C. | W 10-3 |
| Tue Feb 28, 4:00 ET | vs East Carolina Durham, N.C. | W 9-0 |
| Fri Mar 3, 4:00 ET | vs Princeton Durham, N.C. | L 3-7 |
| Sat Mar 4, 1:00 ET | vs Princeton Durham, N.C. | W 21-2 |
| Sun Mar 5, 1:00 ET | vs Princeton Durham, N.C. | W 12-5 |
| Tue Mar 7, 4:00 ET | vs Appalchian State Durham, N.C. | W 5-0 |
| Wed Mar 8, 4:00 ET | vs Northeastern Durham, N.C. | L 1-2 |
| Fri Mar 10, 4:00 ET | vs Wake Forest Durham, N.C. | L 6-8 |
| Sat Mar 11, 1:00 ET | vs Wake Forest Durham, N.C. | W 8-1 |
| Sat Mar 11, 4:00 ET | vs Wake Forest Durham, N.C. | L 3-5 |
| Wed Mar 15, 6:30 ET | vs Presbyterian College Greenville, S.C. | W 15-2 |
| Sat Mar 18, 1:00 ET | at Clemson Clemson, S.C. | W 3-2 |
| Sat Mar 18, 5:00 ET | at Clemson Clemson, S.C. | L 9-14 |
| Sun Mar 19, 1:00 ET | at Clemson Clemson, S.C. | W 11-8 |
| Tue Mar 21, 4:00 ET | vs Towson Durham, N.C. | W 19-3 |
| Thu Mar 23, 7:00 ET | at North Carolina Chapel Hill, N.C. | L 3-6 |
| Fri Mar 24, 6:00 ET | at North Carolina Chapel Hill, N.C. | W 8-5 |
| Sat Mar 25, 2:00 ET | at North Carolina Chapel Hill, N.C. | L 3-5 |
| Tue Mar 28, 4:00 ET | at Liberty Lynchburg, Va. | W 7-3 |
| Fri Mar 31, 6:00 ET | vs Pitt Durham, N.C. | L 1-13 |
| Sat Apr 1, 3:00 ET | vs Pitt Durham, N.C. | W 11-7 |
| Sun Apr 2, 1:00 ET | vs Pitt Durham, N.C. | W 8-0 |
| Tue Apr 4, 6:00 ET | vs Campbell Durham, N.C. | W 15-6 |
| Sun Apr 9, 1:00 ET | vs Virginia Tech Durham, N.C. | W 3-1 |
| Sun Apr 9, 4:00 ET | vs Virginia Tech Durham, N.C. | L 2-5 |
| Tue Apr 11, 6:00 ET | vs Davidson Durham, N.C. | W 19-0 |
| Fri Apr 14, 4:00 ET | at Boston College Brighton, Mass. | W 6-4 |
| Sat Apr 15, 2:00 ET | at Boston College Brighton, Mass. | L 6-9 |
| Sun Apr 16, 1:00 ET | at Boston College Brighton, Mass. | W 6-2 |
| Tue Apr 18, 6:00 ET | vs William & Mary Durham, N.C. | W 7-0 |
| Fri Apr 21, 6:00 ET | vs Louisville Durham, N.C. | W 10-9 |
| Sat Apr 22, 7:00 ET | vs Louisville Durham, N.C. | W 7-6 |
| Sun Apr 23, 1:00 ET | vs Louisville Durham, N.C. | W 4-3 |
| Tue Apr 25, 6:00 ET | at Campbell Buies Creek, N.C. | W 4-2 |
| Wed Apr 26, 6:00 ET | vs High Point Durham, NC | W 11-3 |
| Fri Apr 28, 9:00 ET | at Virginia Charlottesville, Va. | W 17-5 |
| Sat Apr 29, 4:00 ET | at Virginia Charlottesville, Va. | L 2-10 |
| Sun Apr 30, 1:00 ET | at Virginia Charlottesville, Va. | W 7-3 |
| Sun May 7, 1:00 ET | vs Longwood Durham, N.C. | W 13-9 |
| Tue May 9, 6:00 ET | vs Rider Durham, N.C. | L 1-2 |
| Wed May 10, 6:00 ET | vs Rider Durham, N.C. | W 4-3 |
| Fri May 12, 6:00 ET | vs Georgia Tech Durham, N.C. | L 5-8 |
| Sat May 13, 1:00 ET | vs Georgia Tech Durham, N.C. | W 6-5 |
| Sun May 14, 1:00 ET | vs Georgia Tech Durham, N.C. | L 5-8 |
| Tue May 16, 1:00 ET | vs Gardner-Webb Durham, N.C. | L 5-9 |
| Thu May 18, 7:00 ET | at Miami Coral Gables, Fla. | W 5-3 |
| Fri May 19, 7:00 ET | at Miami Coral Gables, Fla. | L 8-10 |
| Sat May 20, 1:00 ET | at Miami Coral Gables, Fla. | L 1-10 |
| Tue May 23, 7:00 ET | vs NC State Durham, N.C. | L 7-8 |
| Fri May 26, 3:00 ET | vs Miami Durham, N.C. | L 6-7 |
| Fri Jun 2, 1:00 ET | vs UNCW Conway, S.C. | W 12-3 |
| Sat Jun 3, 6:00 ET | vs Rider Conway, S.C. | W 2-1 |
| Sun Jun 4, 6:00 ET | vs Coastal Carolina Conway, SC | L 6-8 |
| Mon Jun 5, 6:00 ET | vs Coastal Carolina Conway, SC | W 12-3 |
| Fri Jun 9, 12:00 ET | at Virginia Charlottesville, VA / NCAA Super Regional | W 5-4 |
| Sat Jun 10, 12:00 ET | vs Virginia Charlottesville, VA / NCAA Super Regional | L 4-14 |
| Sun Jun 11, 12:00 ET | vs Virginia Charlottesville, VA / NCAA Super Regional (if necessary) | L 2-12 |