| Date | Game | |
| Sat Nov 28, 2:00 ET | vs Coppin State Cameron Indoor Stadium, Durham, NC | W 81-71 |
| Tue Dec 1, 7:30 ET | vs Michigan State Cameron Indoor Stadium, Durham, NC | L 69-75 |
| Fri Dec 4, 7:00 ET | vs Bellarmine Cameron Indoor Stadium, Durham, NC | W 76-54 |
| Tue Dec 8, 9:30 ET | vs Illinois Cameron Indoor Stadium, Durham, NC | L 68-83 |
| Sat Dec 12, 8:30 ET | vs Charleston Southern Cameron Indoor Stadium, Durham, NC | ACCN |
| Wed Dec 16, 9:00 ET | at Notre Dame Joyce Center, Notre Dame, IN | W 75-65 |
| Sat Dec 19, 2:00 ET | vs Gardner-Webb Cameron Indoor Stadium, Durham, NC | ACCNX |
| Wed Jan 6, 8:30 ET | vs Boston College Cameron Indoor Stadium, Durham, NC | W 83-82 |
| Sat Jan 9, 12:00 ET | vs Wake Forest Cameron Indoor Stadium, Durham, NC | W 79-68 |
| Tue Jan 12, 7:00 ET | at Virginia Tech Cassell Coliseum, Blacksburg, VA | L 67-74 |
| Tue Jan 19, 9:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | L 73-79 |
| Sat Jan 23, 4:00 ET | at Louisville KFC Yum Center, Louisville, KY | L 65-70 |
| Tue Jan 26, 9:00 ET | vs Georgia Tech Cameron Indoor Stadium, Durham, NC | W 75-68 |
| Sat Jan 30, 12:00 ET | vs Clemson Cameron Indoor Stadium, Durham, NC | W 79-53 |
| Mon Feb 1, 7:00 ET | at Miami Watsco Center, Coral Gables, FL | L 75-77 |
| Sat Feb 6, 6:00 ET | vs North Carolina Cameron Indoor Stadium, Durham, NC | L 87-91 |
| Tue Feb 9, 4:30 ET | vs Notre Dame Cameron Indoor Stadium, Durham, NC | L 89-93 |
| Sat Feb 13, 4:00 ET | at NC State PNC Arena, Raleigh, NC | W 69-53 |
| Wed Feb 17, 8:30 ET | at Wake Forest LJVM Coliseum, Winston-Salem, NC | W 84-60 |
| Sat Feb 20, 8:00 ET | vs Virginia Cameron Indoor Stadium, Durham, NC | W 66-65 |
| Mon Feb 22, 7:00 ET | vs Syracuse Cameron Indoor Stadium, Durham, NC | W 85-71 |
| Sat Feb 27, 6:00 ET | vs Louisville Cameron Indoor Stadium, Durham, NC | L 73-80 |
| Tue Mar 2, 8:00 ET | at Georgia Tech McCamish Pavilion, Atlanta, GA | L 77-81 |
| Sat Mar 6, 6:00 ET | at North Carolina Smith Center, Chapel Hill, NC | L 73-91 |
| Tue Mar 9, 4:30 ET | vs Boston College Greensboro, NC | W 86-51 |
| Wed Mar 10, 6:30 ET | at Louisville Greensboro, NC | W 70-56 |