| Date | Game | |
| Tue Nov 9, 9:30 ET | vs Kentucky Madison Square Garden, New York, NY | W 79-71 |
| Fri Nov 12, 7:00 ET | vs Army Cameron Indoor Stadium, Durham, NC | W 82-56 |
| Sat Nov 13, 8:00 ET | vs Campbell Cameron Indoor Stadium, Durham, NC | W 67-56 |
| Tue Nov 16, 7:00 ET | vs Gardner-Webb Cameron Indoor Stadium, Durham, NC | W 92-52 |
| Fri Nov 19, 8:00 ET | vs Lafayette Cameron Indoor Stadium, Durham, NC | W 88-55 |
| Mon Nov 22, 9:00 ET | vs The Citadel Cameron Indoor Stadium, Durham, NC | W 107-81 |
| Fri Nov 26, 10:30 ET | vs Gonzaga T-Mobile Arena, Las Vegas, NV | W 84-81 |
| Tue Nov 30, 9:30 ET | at Ohio State Value City Arena, Columbus, OH | L 66-71 |
| Tue Dec 14, 8:00 ET | vs South Carolina State Cameron Indoor Stadium, Durham, NC | W 103-62 |
| Thu Dec 16, 7:00 ET | vs Appalachian State Cameron Indoor Stadium, Durham, NC | W 92-67 |
| Sat Dec 18, 4:00 ET | vs Elon Cameron Indoor Stadium, Durham, NC | W 87-56 |
| Wed Dec 22, 9:00 ET | vs Virginia Tech Cameron Indoor Stadium, Durham, NC | W 76-65 |
| Tue Jan 4, 9:00 ET | vs Georgia Tech Cameron Indoor Stadium, Durham, NC | W 69-57 |
| Sat Jan 8, 8:00 ET | vs Miami Cameron Indoor Stadium, Durham, NC | L 74-76 |
| Wed Jan 12, 7:00 ET | at Wake Forest LJVM Coliseum, Winston-Salem, NC | W 76-64 |
| Sat Jan 15, 2:00 ET | vs NC State Cameron Indoor Stadium, Durham, NC | W 88-73 |
| Tue Jan 18, 9:00 ET | at Florida State Donald L. Tucker Civic Center, Tallahassee, FL | L 78-79 |
| Sat Jan 22, 12:00 ET | vs Syracuse Cameron Indoor Stadium, Durham, NC | W 79-59 |
| Tue Jan 25, 7:00 ET | vs Clemson Cameron Indoor Stadium, Durham, NC | W 71-69 |
| Sat Jan 29, 12:00 ET | at Louisville KFC Yum Center, Louisville, KY | W 74-65 |
| Mon Jan 31, 7:00 ET | at Notre Dame Purcell Pavilion, Notre Dame, IN | W 57-43 |
| Sat Feb 5, 6:00 ET | at North Carolina Smith Center, Chapel Hill, NC | W 87-67 |
| Mon Feb 7, 7:00 ET | vs Virginia Cameron Indoor Stadium, Durham, NC | L 68-69 |
| Thu Feb 10, 8:00 ET | at Clemson Littlejohn Coliseum, Clemson, SC | W 82-64 |
| Sat Feb 12, 5:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | W 72-61 |
| Tue Feb 15, 7:00 ET | vs Wake Forest Cameron Indoor Stadium, Durham, NC | W 76-74 |
| Sat Feb 19, 6:00 ET | vs Florida State Cameron Indoor Stadium, Durham, NC | W 88-70 |
| Wed Feb 23, 7:00 ET | at Virginia John Paul Jones Arena, Charlottesville, VA | W 65-61 |
| Sat Feb 26, 6:00 ET | at Syracuse Carrier Dome, Syracuse, NY | W 97-72 |
| Tue Mar 1, 8:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | W 86-56 |
| Sat Mar 5, 6:00 ET | vs North Carolina Cameron Indoor Stadium, Durham, NC | L 81-94 |
| Thu Mar 10, 12:00 ET | vs Syracuse Barclays Center, Brooklyn, NY | W 88-79 |
| Fri Mar 11, 7:00 ET | vs Miami Barclays Center, Brooklyn, NY | W 80-76 |
| Sat Mar 12, 8:30 ET | vs TBA Barclays Center, Brooklyn, NY | ESPN |
| Sat Mar 12, 8:30 ET | vs Virginia Tech Brooklyn, N.Y. | L 67-82 |
| Fri Mar 18, 7:10 ET | vs Cal State Fullerton Bon Secours Wellness Arena, Greenville, SC | W 78-61 |
| Sun Mar 20, 5:15 ET | vs Michigan State Bon Secours Wellness Arena, Greenville, SC | W 85-76 |
| Thu Mar 24, 9:30 ET | vs Texas Tech Chase Center, San Francisco, CA | W 78-73 |
| Sat Mar 26, 8:49 ET | vs Arkansas Chase Center, San Francisco, CA | W 78-69 |
| Sat Apr 2, 8:49 ET | vs North Carolina Caesars Superdome, New Orleans, LA | L 77-81 |