| Date | Game | |
| Mon Nov 2, 6:30 ET | vs Army West Point Durham, N.C. | W 84-50 |
| Thu Nov 5, 8:00 ET | vs Coastal Carolina Durham, N.C. | W 113-52 |
| Tue Nov 10, 7:00 ET | vs Michigan State Chicago, Ill. | L 73-79 |
| Fri Nov 13, 8:00 ET | vs SIU Edwardsville Durham, N.C. | W 90-47 |
| Tue Nov 17, 7:00 ET | vs Illinois | ESPN |
| Sat Nov 21, 11:00 ET | vs Washington State Palm Desert, Calif. | ESPN2 |
| Wed Nov 25, 7:00 ET | vs UConn Las Vegas, Nev. | Prime Video |
| Tue Dec 1, 9:30 ET | at Florida Gainesville, Fla. | ESPN |
| Fri Dec 4, 7:00 ET | vs Harvard Durham, N.C. | ESPN2 |
| Tue Dec 8, 9:00 ET | vs Georgia New York, N.Y. | ESPN |
| Tue Dec 15, 7:00 ET | vs Campbell Durham, N.C. | ACCN |
| Thu Dec 17, 8:00 ET | vs Grambling State Durham, N.C. | ACCN |
| Mon Dec 21, 7:00 ET | vs Texas Tech New York, N.Y. | Prime Video |
| Wed Dec 30, 7:30 ET | at Georgia Tech Atlanta, Ga. | ESPN |
| Sat Jan 2, 2:15 ET | vs Cal Durham, N.C. | The CW |
| Tue Jan 5, 7:00 ET | at Syracuse Syracuse, NY | ESPN/2 |
| Sat Jan 9, 2:00 ET | vs Pitt Durham, N.C. | CBS |
| Wed Jan 13, 9:00 ET | vs Stanford Durham, N.C. | ACCN |
| Sat Jan 16, 7:00 ET | at Boston College Chestnut, Hill, Mass. | ACCN |
| Wed Jan 20, 9:00 ET | at Wake Forest Winston-Salem, N.C. | ACCN |
| Sat Jan 23, 2:15 ET | vs Notre Dame Durham, N.C. | The CW |
| Sat Jan 30 | at Clemson Clemson, SC | ESPN/2 |
| Mon Feb 1, 7:00 ET | vs Miami Durham, N.C. | ESPN |
| Sat Feb 6 | at Virginia Charlottesville, VA | ESPN |
| Tue Feb 9, 9:00 ET | at SMU Dallas, Texas | ESPN |
| Sat Feb 13, 5:30 ET | vs North Carolina Durham, N.C. | ABC |
| Tue Feb 16, 7:00 ET | vs Florida State Durham, N.C. | ESPN/2 |
| Sat Feb 20, 8:00 ET | vs Gonzaga Detroit, Mich. | Prime Video |
| Wed Feb 24, 7:00 ET | at Louisville Louisville, Ky. | ESPN |
| Sat Feb 27, 12:00 ET | vs NC State Durham, NC | ESPN |
| Mon Mar 1, 7:00 ET | vs Virginia Durham, N.C. | ESPN |
| Sat Mar 6 | at North Carolina Chapel Hill | ESPN |