| Date | Game | |
| Fri Feb 17, 3:00 ET | vs Bucknell Louisville, Ky. | W 7-1 |
| Sat Feb 18, 1:00 ET | vs Bucknell Louisville, Ky. | W 11-2 |
| Sun Feb 19, 1:00 ET | vs Bucknell Louisville, Ky. | W 5-3 |
| Wed Feb 22, 2:00 ET | vs Xavier Louisville, Ky. | W 12-8 |
| Fri Feb 24, 3:00 ET | vs Bowling Green Louisville, Ky. | W 2-1 |
| Sat Feb 25, 1:00 ET | vs Bowling Green Louisville, Ky. | L 6-9 |
| Sun Feb 26, 1:00 ET | vs Bowling Green Louisville, Ky. | W 14-1 |
| Tue Feb 28, 3:00 ET | vs Eastern Kentucky Louisville, Ky. | W 11-0 |
| Fri Mar 3, 8:00 ET | vs Texas A&M Houston, Texas | W 14-5 |
| Sat Mar 4, 4:00 ET | vs TCU Houston, Texas | W 3-2 |
| Sun Mar 5, 12:00 ET | vs Michigan Houston, Texas | W 10-0 |
| Tue Mar 7, 3:00 ET | vs Morehead State Louisville, Ky. | W 11-1 |
| Fri Mar 10, 3:00 ET | vs Dayton Louisville, Ky. | W 11-7 |
| Sat Mar 11, 1:00 ET | vs Dayton Louisville, Ky. | W 6-2 |
| Sun Mar 12, 1:00 ET | vs Dayton Louisville, Ky. | W 5-1 |
| Wed Mar 15, 11:30 AM ET | vs Miami Louisville, KY | W 6-4 |
| Fri Mar 17, 6:00 ET | vs Georgia Tech Louisville, Ky. | W 8-7 |
| Sat Mar 18, 1:00 ET | vs Georgia Tech Louisville, Ky. | L 4-10 |
| Sun Mar 19, 1:00 ET | vs Georgia Tech Louisville, Ky. | W 9-3 |
| Tue Mar 21, 5:00 ET | vs Western Kentucky Louisville, Ky. | W 15-8 |
| Fri Mar 24, 3:00 ET | at Notre Dame South Bend, Ind. | L 3-4 |
| Sun Mar 26, 11:00 AM ET | at Notre Dame South Bend, Ind. | L 4-5 |
| Sun Mar 26, 2:30 ET | at Notre Dame South Bend, Ind. | W 2-1 |
| Tue Mar 28, 6:00 ET | at Cincinnati Cincinnati, Ohio | W 14-1 |
| Fri Mar 31, 6:00 ET | at NC State Raleigh, N.C. | L 5-6 |
| Sat Apr 1, 6:00 ET | at NC State Raleigh, N.C. | L 0-10 |
| Sun Apr 2, 12:00 ET | at NC State Raleigh, N.C. | W 6-1 |
| Tue Apr 4, 6:00 ET | vs Lipscomb Louisville, Ky. | L 7-12 |
| Thu Apr 6, 6:00 ET | vs Boston College Louisville, Ky. | W 6-4 |
| Fri Apr 7, 6:00 ET | vs Boston College Louisville, Ky. | W 9-8 |
| Sat Apr 8, 12:00 ET | vs Boston College Louisville, Ky. | W 4-2 |
| Wed Apr 12, 7:00 ET | vs Bellarmine Louisville, KY | W 14-2 |
| Fri Apr 14, 6:00 ET | vs Wake Forest Louisville, Ky. | L 5-11 |
| Sat Apr 15, 1:00 ET | vs Wake Forest Louisville, Ky. | L 0-3 |
| Sun Apr 16, 1:00 ET | vs Wake Forest Louisville, Ky. | W 7-2 |
| Tue Apr 18, 6:00 ET | at Indiana Bloomington, Ind. | L 3-7 |
| Fri Apr 21, 6:00 ET | at Duke Durham, N.C. | L 9-10 |
| Sat Apr 22, 7:00 ET | at Duke Durham, N.C. | L 6-7 |
| Sun Apr 23, 1:00 ET | at Duke Durham, N.C. | L 3-4 |
| Tue Apr 25, 7:00 ET | at Kentucky Lexington, Ky. | W 7-0 |
| Thu Apr 27, 4:00 ET | vs Miami Louisville, KY | L 5-6 |
| Fri Apr 28, 6:00 ET | vs Miami Louisville, Ky. | W 11-0 |
| Sat Apr 29, 1:00 ET | vs Miami Louisville, Ky. | L 7-10 |
| Tue May 2, 6:00 ET | at Bellarmine Louisville, Ky. | W 18-7 |
| Fri May 5, 4:00 ET | at Clemson Clemson, S.C. | L 3-6 |
| Sat May 6, 2:00 ET | at Clemson Clemson, S.C. | L 3-4 |
| Sun May 7, 12:00 ET | at Clemson Louisville, Ky. | L 3-7 |
| Tue May 9, 6:00 ET | vs Vanderbilt Louisville, Ky. | L 8-12 |
| Fri May 12, 6:00 ET | at Virginia Charlottesville, Va. | L 5-15 |
| Sat May 13, 7:00 ET | at Virginia Charlottesville, Va. | L 1-4 |
| Sun May 14, 1:00 ET | at Virginia Charlottesville, Va. | L 3-8 |
| Tue May 16, 6:00 ET | vs Northern Kentucky Louisville, Ky. | W 18-5 |
| Thu May 18, 7:00 ET | vs Florida State Louisville, Ky. | W 7-4 |
| Fri May 19, 6:00 ET | vs Florida State Louisville, Ky. | L 4-7 |
| Sat May 20, 1:00 ET | vs Florida State Louisville, Ky. | L 2-6 |