| Date | Game | |
| Fri Feb 14, 8:00 ET | vs Texas Arlington, Texas | W 4-3 |
| Sat Feb 15, 4:00 ET | vs Oklahoma State Arlington, Texas | L 3-12 |
| Sun Feb 16, 11:30 AM ET | vs Arizona Arlington, Texas | W 13-1 |
| Sat Feb 22, 1:00 ET | vs Western Michigan Louisville, Ky. | W 14-3 |
| Sun Feb 23, 1:00 ET | vs Western Michigan Louisville, Ky. | W 7-2 |
| Mon Feb 24, 3:00 ET | vs Western Michigan Louisville, Ky. | W 10-4 |
| Wed Feb 26, 3:00 ET | vs Butler Louisville, Ky. | W 15-11 |
| Fri Feb 28, 3:00 ET | vs St. John's Louisville, Ky. | W 8-6 |
| Sat Mar 1, 1:00 ET | vs St. John's Louisville, Ky. | L 7-13 |
| Sun Mar 2, 1:00 ET | vs St. John's Louisville, Ky. | W 6-2 |
| Tue Mar 4, 3:00 ET | vs Morehead State Louisville, Ky. | W 9-8 |
| Fri Mar 7, 12:00 ET | vs UIC Louisville, Ky. | W 10-2 |
| Sat Mar 8, 1:00 ET | vs UIC Louisville, Ky. | W 13-3 |
| Sun Mar 9, 1:00 ET | vs UIC Louisville, Ky. | W 5-2 |
| Tue Mar 11, 3:00 ET | vs Lipscomb Louisville, Ky. | W 13-0 |
| Wed Mar 12, 8:00 ET | vs Oakland Louisville, Ky. | W 13-5 |
| Fri Mar 14, 3:00 ET | vs North Carolina Louisville, Ky. | W 8-7 |
| Fri Mar 14, 7:00 ET | vs North Carolina Louisville, Ky. | L 4-6 |
| Sun Mar 16, 3:00 ET | vs North Carolina Louisville, Ky. | W 5-0 |
| Tue Mar 18, 6:00 ET | vs Northern Kentucky Louisville, Ky. | W 11-1 |
| Fri Mar 21, 4:00 ET | at Virginia Tech Blacksburg, Va. | L 4-5 |
| Sat Mar 22, 3:00 ET | at Virginia Tech Blacksburg, Va. | W 12-8 |
| Sun Mar 23, 1:00 ET | at Virginia Tech Blacksburg, Va. | L 4-11 |
| Tue Mar 25, 6:00 ET | at Cincinnati Cincinnati, Ohio | L 2-12 |
| Fri Mar 28, 6:00 ET | vs Cal Louisville, Ky. | W 11-10 |
| Sat Mar 29, 2:00 ET | vs Cal Louisville, Ky. | L 10-14 |
| Sun Mar 30, 12:00 ET | vs Cal Louisville, Ky. | L 10-14 |
| Tue Apr 1, 6:00 ET | at Indiana Bloomington, Ind. | W 6-4 |
| Fri Apr 4, 2:30 ET | vs Boston College Louisville, Ky. | W 12-8 |
| Fri Apr 4, 6:00 ET | vs Boston College Louisville, Ky. | W 17-5 |
| Fri Apr 4, 6:00 ET | vs Boston College Louisville, Ky. | W 17-5 |
| Fri Apr 4, 8:00 ET | vs Boston College Louisville, Ky. | W 17-5 |
| Sun Apr 6, 11:00 AM ET | vs Boston College Louisville, Ky. | W 12-1 |
| Tue Apr 8, 7:00 ET | vs Kentucky Louisville, Ky. | W 4-3 |
| Fri Apr 11, 6:00 ET | at NC State Raleigh, N.C. | L 11-13 |
| Sat Apr 12, 3:00 ET | at NC State Raleigh, N.C. | W 25-8 |
| Sun Apr 13, 1:00 ET | at NC State Raleigh, N.C. | L 1-11 |
| Tue Apr 15, 6:00 ET | vs Western Kentucky Louisville, Ky. | W 5-2 |
| Thu Apr 17, 7:00 ET | at Clemson Clemson, S.C. | L 6-7 |
| Fri Apr 18, 5:00 ET | at Clemson Clemson, S.C. | L 1-2 |
| Sat Apr 19, 1:00 ET | at Clemson Clemson, S.C. | W 8-6 |
| Tue Apr 22, 6:30 ET | at Kentucky Lexington, Ky. | L 5-17 |
| Fri Apr 25, 8:00 ET | vs Florida State Louisville, Ky. | L 2-10 |
| Sat Apr 26, 2:00 ET | vs Florida State Louisville, Ky. | W 9-4 |
| Sun Apr 27, 3:00 ET | vs Florida State Louisville, Ky. | W 14-2 |
| Tue Apr 29, 2:00 ET | vs Eastern Kentucky Louisville, Ky. | W 11-5 |
| Thu May 1, 7:00 ET | at Notre Dame South Bend, Ind. | W 3-2 |
| Fri May 2, 6:30 ET | at Notre Dame South Bend, Ind. | L 3-10 |
| Sat May 3, 2:00 ET | at Notre Dame South Bend, Ind. | L 4-7 |
| Tue May 6, 7:00 ET | vs Vanderbilt Louisville, Ky. | W 5-4 |
| Fri May 9, 6:00 ET | at Georgia Tech Atlanta, GA | W 16-2 |
| Sun May 11, 10:00 AM ET | at Georgia Tech Atlanta, Ga. | L 0-6 |
| Sun May 11, 1:00 ET | at Georgia Tech Atlanta, GA | L 1-2 |
| Tue May 13, 6:00 ET | vs Bellarmine Louisville, Ky. | L 9-10 |
| Thu May 15, 6:00 ET | vs Wake Forest Louisville, Ky. | L 4-14 |
| Fri May 16, 1:00 ET | vs Wake Forest Louisville, Ky. | L 4-5 |
| Sat May 17, 12:00 ET | vs Wake Forest Louisville, Ky. | W 14-9 |
| Tue May 20, 5:00 ET | vs Pitt Durham, N.C. (ACC Championship) | L 11-13 |
| Fri May 30, 2:00 ET | vs East Tennessee State Nashville, Tenn. | W 8-3 |
| Sat May 31, 9:00 ET | at Vanderbilt Nashville, Tenn. | W 3-2 |
| Sun Jun 1, 9:00 ET | vs Wright State Nashville, Tenn. | W 6-0 |
| Fri Jun 6, 3:00 ET | vs Miami Louisville, Ky. | W 8-1 |
| Sat Jun 7, 11:00 AM ET | vs Miami Louisville, Ky. | L 6-9 |
| Sun Jun 8, 12:00 ET | vs Miami Louisville, Ky. | W 3-2 |
| Fri Jun 13, 7:00 ET | vs Oregon State Omaha, Neb. | L 3-4 |
| Sun Jun 15, 2:00 ET | vs Arizona | ESPN |