| Date | Game | |
| Fri Feb 13, 2:00 ET | vs Michigan State Louisville, Ky. | L 3-4 |
| Sat Feb 14, 1:00 ET | vs Michigan State Louisville, Ky. | L 4-13 |
| Sun Feb 15, 1:00 ET | vs Michigan State Louisville, Ky. | W 9-1 |
| Tue Feb 17, 3:00 ET | vs Xavier Louisville, Ky. | W 23-11 |
| Fri Feb 20, 4:00 ET | vs Nebraska Arlington, Texas | W 4-2 |
| Sat Feb 21, 12:00 ET | vs Michigan Arlington, Texas | L 5-8 |
| Sun Feb 22, 11:30 AM ET | vs Auburn Arlington, Texas | L 6-10 |
| Wed Feb 25, 2:30 ET | vs Eastern Kentucky Louisville, Ky. | W 6-5 |
| Fri Feb 27, 3:00 ET | vs Central Michigan Louisville, Ky. | W 16-2 |
| Sat Feb 28, 1:00 ET | vs Central Michigan Louisville, Ky. | W 9-8 |
| Sun Mar 1, 1:00 ET | vs Central Michigan Louisville, Ky. | W 7-5 |
| Tue Mar 3, 3:00 ET | vs Morehead State Louisville, Ky. | L 5-13 |
| Fri Mar 6, 3:00 ET | vs Seton Hall Louisville, Ky. | W 16-1 |
| Sat Mar 7, 5:30 ET | vs Seton Hall Louisville, Ky. | W 13-3 |
| Sun Mar 8, 1:00 ET | vs Seton Hall Louisville, Ky. | W 6-2 |
| Tue Mar 10, 3:00 ET | vs Marshall Louisville, Ky. | W 16-5 |
| Wed Mar 11, 10:00 AM ET | vs Marshall Louisville, Ky. | W 18-8 |
| Fri Mar 13, 6:00 ET | vs Notre Dame Louisville, Ky. | L 11-14 |
| Sat Mar 14, 6:00 ET | vs Notre Dame Louisville, Ky. | W 8-7 |
| Sun Mar 15, 1:00 ET | vs Notre Dame Louisville, Ky. | W 21-12 |
| Wed Mar 18, 4:00 ET | vs Northern Kentucky Louisville, Ky. | W 16-1 |
| Fri Mar 20, 8:00 ET | at North Carolina Chapel Hill, N.C. | L 1-11 |
| Sat Mar 21, 2:00 ET | at North Carolina Chapel Hill, N.C. | W 2-0 |
| Sun Mar 22, 1:00 ET | at North Carolina Chapel Hill, N.C. | L 6-7 |
| Tue Mar 24, 7:00 ET | at Western Kentucky Bowling Green, Ky. | L 5-10 |
| Fri Mar 27, 5:00 ET | vs Pitt Louisville, Ky. | L 3-4 |
| Sat Mar 28, 2:00 ET | vs Pitt Louisville, Ky. | W 8-5 |
| Sun Mar 29, 1:00 ET | vs Pitt Louisville, Ky. | L 7-13 |
| Tue Mar 31, 1:00 ET | at Eastern Kentucky Richmond, Ky. | W 17-7 |
| Thu Apr 2, 8:00 ET | at Duke Durham, N.C. | L 3-6 |
| Fri Apr 3, 6:00 ET | at Duke Durham, N.C. | L 8-10 |
| Sat Apr 4, 12:00 ET | at Duke Durham, N.C. | W 9-4 |
| Tue Apr 7, 5:30 ET | at Kentucky Lexington, Ky. | L 2-4 |
| Fri Apr 10, 6:00 ET | vs Stanford Louisville, Ky. | L 2-12 |
| Sat Apr 11, 2:00 ET | vs Stanford Louisville, Ky. | W 10-0 |
| Sun Apr 12, 1:00 ET | vs Stanford Louisville, Ky. | L 4-6 |
| Tue Apr 14, 6:00 ET | vs Western Kentucky Louisville, Ky. | W 7-3 |
| Fri Apr 17, 9:00 ET | at Cal Berkeley, Calif. | L 5-8 |
| Sat Apr 18, 5:00 ET | at Cal Berkeley, Calif. | L 5-6 |
| Sun Apr 19, 4:00 ET | at Cal Berkeley, Calif. | W 8-5 |
| Tue Apr 21, 7:00 ET | vs Kentucky Louisville, Ky. | W 14-10 |
| Fri Apr 24, 6:00 ET | vs Clemson Louisville, Ky. | W 13-10 |
| Sat Apr 25, 7:00 ET | vs Clemson Louisville, Ky. | W 11-6 |
| Sun Apr 26, 2:00 ET | vs Clemson Louisville, Ky. | W 7-5 |
| Tue Apr 28, 5:00 ET | vs Indiana Louisville, Ky. | L 6-10 |
| Thu Apr 30, 7:00 ET | at Wake Forest Winston-Salem, N.C. | L 8-9 |
| Fri May 1, 6:00 ET | at Wake Forest Winston-Salem, N.C. | L 5-6 |
| Sat May 2, 1:00 ET | at Wake Forest Winston-Salem, N.C. | L 5-7 |
| Tue May 5, 6:00 ET | at Vanderbilt Nashville, Tenn. | L 6-12 |
| Thu May 7, 7:00 ET | at Miami | ACCNX |
| Fri May 8, 7:00 ET | at Miami | ACCNX |
| Sat May 9, 2:00 ET | at Miami | ACCNX |
| Tue May 12, 6:00 ET | vs Bellarmine Louisville, Ky. | ACCNX |
| Thu May 14, 6:00 ET | vs Virginia Louisville, Ky. | ACCNX |
| Fri May 15, 6:00 ET | vs Virginia Louisville, Ky. | ACCNX |
| Sat May 16, 1:00 ET | vs Virginia Louisville, Ky. | ACCNX |