| Date | Game | |
| Fri Aug 29, 12:00 ET | vs Michigan State Louisville, Ky. | W 6-1 |
| Sun Aug 31, 1:00 ET | vs Ohio University | ACCNX |
| Sat Sep 6, 12:00 ET | vs Drexel Bloomington, Ind. | |
| Sun Sep 7, 1:00 ET | at Indiana Bloomington, Ind. | |
| Fri Sep 12, 6:00 ET | vs Northwestern Louisville, Ky. | |
| Sun Sep 14, 1:30 ET | vs Iowa Louisville, Ky. | |
| Fri Sep 19, 4:00 ET | vs Ohio State Louisville, Ky. | |
| Sun Sep 21, 12:00 ET | at Saint Joseph's Philadelphia, Pa. | |
| Fri Sep 26, 8:00 ET | at Stanford Stanford, Calif. | |
| Fri Oct 3, 5:00 ET | vs Wake Forest Louisville, Ky. | |
| Tue Oct 7, 5:00 ET | vs Bellarmine Louisville, Ky. | |
| Fri Oct 10, 6:00 ET | at Duke Durham, N.C. | |
| Sun Oct 12, 12:00 ET | at North Carolina Chapel Hill, N.C. | |
| Fri Oct 17, 6:00 ET | vs California Louisville, Ky. | |
| Fri Oct 24, 3:00 ET | vs Virginia Louisville, Ky. | |
| Sun Oct 26, 12:00 ET | at Boston College Newton, Mass. | |
| Sat Nov 1, 12:00 ET | vs Syracuse Louisville, Ky. | |