| Date | Game | |
| Mon Sep 6, 8:00 ET | at Ole Miss Atlanta, Ga. | L 24-43 |
| Sat Sep 11, 7:00 ET | vs Eastern Kentucky Louisville, Ky. | W 30-3 |
| Fri Sep 17, 7:30 ET | vs UCF Louisville, Ky. | W 42-35 |
| Sat Sep 25, 3:30 ET | at Florida State Tallahassee, Fla. | W 31-23 |
| Sat Oct 2, 12:30 ET | at Wake Forest Winston-Salem, N.C. | L 34-37 |
| Sat Oct 9 | vs Virginia Louisville, Ky. | L 33-34 |
| Sat Oct 23, 4:00 ET | vs Boston College Louisville, Ky. | W 28-14 |
| Sat Oct 30, 7:30 ET | at NC State Raleigh, N.C. | L 13-28 |
| Sat Nov 6, 7:30 ET | vs Clemson Louisville, Ky. | L 24-30 |
| Sat Nov 13, 12:00 ET | vs Syracuse Louisville, Ky. | W 41-3 |
| Thu Nov 18, 7:30 ET | at Duke Durham, N.C. | W 62-22 |
| Sat Nov 27, 7:30 ET | vs Kentucky Louisville, Ky. | L 21-52 |
| Tue Dec 28, 3:15 ET | vs Air Force First Responder Bowl: Gerald J. Ford Stadium, Dallas, TX | L 28-31 |