| Date | Game | |
| Fri Sep 1, 7:30 ET | vs Georgia Tech Atlanta, Ga. | W 39-34 |
| Thu Sep 7 | vs Murray State Louisville, KY | W 56-0 |
| Sat Sep 16 | vs Indiana Indianapolis, Ind. | W 21-14 |
| Sat Sep 23 | vs Boston College Louisville, Ky. | W 56-28 |
| Fri Sep 29, 7:00 ET | at NC State Raleigh, N.C. | W 13-10 |
| Sat Oct 7 | vs Notre Dame Louisville, Ky. | W 33-20 |
| Sat Oct 14, 6:30 ET | at Pittsburgh Pittsburgh, PA | L 21-38 |
| Sat Oct 28, 3:30 ET | vs Duke Louisville, Ky. | W 23-0 |
| Sat Nov 4, 3:30 ET | vs Virginia Tech LOUISVILLE, KY | W 34-3 |
| Thu Nov 9 | vs Virginia Louisville, Ky. | W 31-24 |
| Sat Nov 18 | at Miami Coral Gables, FL | W 38-31 |
| Sat Nov 25 | vs Kentucky LOUISVILLE, KY | L 31-38 |
| Sat Dec 2, 8:00 ET | vs Florida State Charlotte, N.C. | L 6-16 |
| Wed Dec 27, 8:00 ET | vs USC San Diego, Calif. | L 28-42 |