| Date | Game | |
| Sat Aug 30, 3:00 ET | vs Eastern Kentucky Louisville, Ky. | W 51-17 |
| Fri Sep 5, 7:00 ET | vs James Madison Louisville, Ky. | W 28-14 |
| Sat Sep 20, 12:00 ET | vs Bowling Green Louisville, Ky. | W 40-17 |
| Sat Sep 27, 12:00 ET | at Pitt Pittsburgh, Pa. | W 34-27 |
| Sat Oct 4, 3:30 ET | vs Virginia Louisville, Ky. | L 27-30 |
| Fri Oct 17, 7:00 ET | at Miami Coral Gables, Fla. | W 24-21 |
| Sat Oct 25, 7:30 ET | vs Boston College Louisville, Ky. | W 38-24 |
| Sat Nov 1, 3:00 ET | at Virginia Tech | The CW |
| Sat Nov 8, 7:00 ET | vs California Louisville, Ky. | TBA |
| Fri Nov 14, 7:30 ET | vs Clemson Louisville, Ky. | ESPN |
| Sat Nov 22 | at SMU Dallas, Texas | |
| Sat Nov 29 | vs Kentucky Louisville, Ky. | |