| Date | Game | |
| Wed Nov 25, 4:05 ET | vs Evansville KFC Yum Center, Louisville, KY | W 79-44 |
| Fri Nov 27, 4:00 ET | vs Seton Hall KFC Yum Center, Louisville, KY | W 71-70 |
| Sun Nov 29, 6:00 ET | vs Prairie View A&M KFC Yum Center, Louisville, KY | W 86-64 |
| Tue Dec 1, 6:00 ET | vs Western Kentucky KFC Yum Center, Louisville, KY | W 75-54 |
| Sat Dec 19, 12:00 ET | at Wisconsin Kohl Center, Madison WI | L 48-85 |
| Tue Dec 22, 7:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | W 64-54 |
| Tue Dec 22, 7:00 ET | vs Pittsburgh KFC Yum Center, Louisville, KY | RSN |
| Sat Dec 26, 1:00 ET | vs Kentucky KFC Yum Center, Louisville, KY | W 62-59 |
| Sat Jan 2, 12:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | W 76-64 |
| Wed Jan 6, 6:30 ET | vs Virginia Tech KFC Yum Center, Louisville, KY | W 73-71 |
| Wed Jan 13, 8:30 ET | at Wake Forest LJVM Coliseum, Winston-Salem, NC | W 77-65 |
| Sat Jan 16, 8:00 ET | at Miami Watsco Center, Coral Gables, FL | L 72-78 |
| Mon Jan 18, 7:00 ET | vs Florida State KFC Yum Center, Louisville, KY | L 65-78 |
| Sat Jan 23, 4:00 ET | vs Duke KFC Yum Center, Louisville, KY | W 70-65 |
| Wed Jan 27, 9:00 ET | at Clemson Littlejohn Coliseum, Clemson, SC | L 50-54 |
| Mon Feb 1, 2:00 ET | vs Georgia Tech KFC Yum Center, Louisville, KY | W 74-58 |
| Sat Feb 20, 6:00 ET | at North Carolina Smith Center, Chapel Hill, NC | L 54-99 |
| Tue Feb 23, 7:00 ET | vs Notre Dame KFC Yum Center, Louisville, KY | W 69-57 |
| Sat Feb 27, 6:00 ET | at Duke Cameron Indoor Stadium, Durham, NC | W 80-73 |
| Sat Mar 6, 4:00 ET | vs Virginia KFC Yum Center, Louisville, KY | L 58-68 |
| Wed Mar 10, 6:30 ET | vs Duke Greensboro, NC | L 56-70 |