| Date | Game | |
| Tue Nov 9, 9:00 ET | vs Southern KFC Yum Center, Louisville, KY | W 72-60 |
| Fri Nov 12, 7:00 ET | vs Furman KFC Yum Center, Louisville, KY | L 72-80 |
| Mon Nov 15, 8:00 ET | vs Navy KFC Yum Center, Louisville, KY | W 77-60 |
| Sat Nov 20, 2:00 ET | vs Detroit Mercy KFC Yum Center, Louisville, KY | W 73-67 |
| Thu Nov 25, 9:30 ET | vs Mississippi State Baha Mar Convention Center, Nassau, Bahamas | W 72-58 |
| Sat Nov 27, 10:00 AM ET | vs Maryland Baha Mar Convention Center, Nassau, Bahamas | W 63-55 |
| Wed Dec 1, 7:15 ET | at Michigan State Breslin Center, E. Lansing, MI | L 64-73 |
| Sat Dec 4, 2:00 ET | at NC State PNC Arena, Raleigh, NC | W 73-68 |
| Fri Dec 10, 8:00 ET | vs DePaul KFC Yum Center, Louisville, KY | L 55-62 |
| Tue Dec 14, 6:00 ET | vs SE Louisiana KFC Yum Center, Louisville, KY | W 86-60 |
| Sat Dec 18, 3:00 ET | at Western Kentucky E.A. Diddle Arena, Bowling Green, KY | L 72-82 |
| Wed Dec 29, 8:00 ET | vs Wake Forest KFC Yum Center, Louisville, KY | W 73-69 |
| Sun Jan 2, 6:00 ET | at Georgia Tech McCamish Pavilion, Atlanta, GA | W 67-64 |
| Wed Jan 5, 7:00 ET | vs Pittsburgh KFC Yum Center, Louisville, KY | W 75-72 |
| Sat Jan 8, 8:00 ET | at Florida State Donald L. Tucker Civic Center, Tallahassee, FL | L 70-79 |
| Wed Jan 12, 9:00 ET | vs NC State KFC Yum Center, Louisville, KY | L 63-79 |
| Sat Jan 15, 4:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | L 53-65 |
| Wed Jan 19, 7:00 ET | vs Boston College KFC Yum Center, Louisville, KY | W 67-54 |
| Sat Jan 22, 4:00 ET | vs Notre Dame KFC Yum Center, Louisville, KY | L 70-82 |
| Mon Jan 24, 7:00 ET | at Virginia John Paul Jones Arena, Charlottesville, VA | L 52-64 |
| Sat Jan 29, 12:00 ET | vs Duke KFC Yum Center, Louisville, KY | L 65-74 |
| Tue Feb 1, 8:00 ET | vs North Carolina KFC Yum Center, Louisville, KY | L 83-90 |
| Sat Feb 5, 2:00 ET | at Syracuse Carrier Dome, Syracuse, NY | L 69-92 |
| Wed Feb 9, 7:00 ET | at Notre Dame Purcell Pavilion, Notre Dame, IN | L 57-63 |
| Wed Feb 16, 7:00 ET | vs Miami KFC Yum Center, Louisville, KY | L 63-70 |
| Sat Feb 19, 3:00 ET | vs Clemson KFC Yum Center, Louisville, KY | W 70-61 |
| Mon Feb 21, 7:00 ET | at North Carolina Smith Center, Chapel Hill, NC | L 63-70 |
| Sat Feb 26, 7:00 ET | at Wake Forest LJVM Coliseum, Winston-Salem, NC | L 77-99 |
| Tue Mar 1, 9:00 ET | at Virginia Tech Cassell Coliseum, Blacksburg, VA | L 43-75 |
| Sat Mar 5, 12:00 ET | vs Virginia KFC Yum! Center, Louisville, KY | L 61-71 |
| Tue Mar 8, 7:00 ET | vs Georgia Tech Barclays Center, Brooklyn, NY | W 84-74 |
| Wed Mar 9, 9:30 ET | vs Virginia Barclays Center, Brooklyn, NY | L 50-51 |