| Date | Game | |
| Wed Nov 9, 9:00 ET | vs Bellarmine Louisville, KY | L 66-67 |
| Sat Nov 12, 1:00 ET | vs Wright State Louisville, KY | L 72-73 |
| Tue Nov 15, 6:00 ET | vs Appalachian State Louisville, KY | L 60-61 |
| Mon Nov 21, 5:00 ET | vs Arkansas Lahaina, Maui, Hawaii | L 54-80 |
| Tue Nov 22, 2:30 ET | vs Texas Tech Lahaina, Maui, Hawaii | L 38-70 |
| Wed Nov 23, 7:30 ET | vs Cincinnati Lahaina, Maui, Hawaii | L 62-81 |
| Tue Nov 29, 7:00 ET | vs Maryland Louisville, KY | L 54-79 |
| Sun Dec 4, 1:00 ET | vs Miami Louisville, KY | L 53-80 |
| Sat Dec 10, 1:00 ET | at Florida State Tallahassee, FL | L 53-75 |
| Wed Dec 14, 9:00 ET | vs Western Kentucky Louisville, KY | W 94-83 |
| Sat Dec 17, 2:00 ET | vs Florida A&M Louisville, KY | W 61-55 |
| Tue Dec 20, 6:00 ET | vs Lipscomb Louisville, KY | L 67-75 |
| Thu Dec 22, 7:00 ET | at NC State Raleigh, NC | L 64-76 |
| Sat Dec 31, 12:00 ET | at Kentucky Lexington, KY | L 63-86 |
| Tue Jan 3, 7:00 ET | vs Syracuse Louisville, KY | L 69-70 |
| Sat Jan 7, 3:00 ET | vs Wake Forest Louisville, KY | L 72-80 |
| Wed Jan 11, 9:00 ET | at Clemson Clemson, SC | L 70-83 |
| Sat Jan 14, 2:00 ET | vs North Carolina Louisville, Ky. | L 59-80 |
| Wed Jan 18, 7:00 ET | vs Pittsburgh Louisville, KY | L 54-75 |
| Wed Jan 25, 9:00 ET | at Boston College Chestnut Hill, MA | L 65-75 |
| Sat Jan 28, 12:00 ET | at Notre Dame South Bend, Ind. | L 62-76 |
| Wed Feb 1, 7:00 ET | vs Georgia Tech Louisville, KY | W 68-58 |
| Sat Feb 4, 2:00 ET | vs Florida State Louisville, KY | L 78-81 |
| Tue Feb 7, 7:00 ET | at Pittsburgh Pittsburgh, PA | L 57-91 |
| Sat Feb 11, 7:00 ET | at Miami Coral Gables, FL | L 85-93 |
| Wed Feb 15, 7:00 ET | vs Virginia Louisville, KY | L 58-61 |
| Sat Feb 18, 7:00 ET | vs Clemson Louisville, KY | W 83-73 |
| Mon Feb 20, 7:00 ET | at Duke Durham, NC | L 62-79 |
| Sat Feb 25, 2:00 ET | at Georgia Tech Atlanta, GA | L 67-83 |
| Tue Feb 28, 9:00 ET | vs Virginia Tech Louisville, KY | L 54-71 |
| Sat Mar 4, 2:00 ET | at Virginia Charlottesville, VA | L 60-75 |
| Tue Mar 7, 4:30 ET | vs Boston College Greensboro, NC/New York Life ACC Tournament | L 62-80 |