| Date | Game | |
| Fri Oct 24, 7:30 ET | vs #19 Kansas LOUISVILLE, KY | L 82-90 |
| Tue Oct 28, 7:00 ET | vs Bucknell LOUISVILLE, KY | W 99-76 |
| Mon Nov 3, 9:00 ET | vs South Carolina State Louisville, KY | W 104-45 |
| Thu Nov 6, 7:00 ET | vs Jackson State Louisville, KY | W 106-70 |
| Tue Nov 11, 8:00 ET | vs Kentucky Louisville, KY | W 96-88 |
| Sat Nov 15, 12:00 ET | vs Ohio Louisville, KY | W 106-81 |
| Fri Nov 21, 6:30 ET | vs Cincinnati Cincinnati, Ohio | Heritage Bank Center | W 74-64 |
| Mon Nov 24, 7:00 ET | vs Eastern Michigan Louisville, KY | W 87-46 |
| Wed Nov 26, 9:00 ET | vs NJIT Louisville, KY | W 104-47 |
| Wed Dec 3, 7:15 ET | at Arkansas Fayetteville, Ark. | L 80-89 |
| Sat Dec 6, 2:15 ET | vs Indiana Indianapolis, Ind. | Gainbridge Fieldhouse | W 87-78 |
| Sat Dec 13, 3:30 ET | vs Memphis Louisville, KY | W 99-73 |
| Tue Dec 16, 7:00 ET | at Tennessee Knoxville, Tenn. | L 62-83 |
| Sat Dec 20, 12:00 ET | vs Montana Louisville, KY | W 94-54 |
| Tue Dec 30, 9:00 ET | at California Berkeley, Calif. | W 90-70 |
| Fri Jan 2, 8:00 ET | at Stanford Stanford, Calif. | L 76-80 |
| Tue Jan 6, 7:00 ET | vs Duke Louisville, KY | L 73-84 |
| Sat Jan 10, 12:00 ET | vs Boston College Louisville, KY | W 75-62 |
| Tue Jan 13, 7:00 ET | vs Virginia | ESPN2 |
| Sat Jan 17, 8:00 ET | at Pittsburgh Pittsburgh, Pa. | |
| Sat Jan 24, 3:30 ET | vs Virginia Tech Louisville, KY | The CW |
| Mon Jan 26, 7:00 ET | at Duke Durham, N.C. | ESPN |
| Sat Jan 31, 2:00 ET | vs SMU Louisville, KY | ESPN/2 |
| Wed Feb 4, 7:00 ET | vs Notre Dame Louisville, KY | ESPN2/U |
| Sat Feb 7, 12:00 ET | at Wake Forest Winston-Salem, N.C. | ACCN |
| Mon Feb 9, 7:00 ET | vs NC State Louisville, KY | ESPN |
| Sat Feb 14, 4:00 ET | vs Baylor Fort Worth, Texas | Dickies Arena | ESPN |
| Tue Feb 17, 7:00 ET | at SMU Dallas, Texas | |
| Sat Feb 21, 2:15 ET | vs Georgia Tech Louisville, KY | The CW |
| Mon Feb 23, 7:00 ET | at North Carolina Chapel Hill, N.C. | ESPN |
| Sat Feb 28 | at Clemson Clemson, S.C. | ESPN/2 |
| Tue Mar 3, 9:00 ET | vs Syracuse Louisville, KY | ACCN |
| Sat Mar 7, 2:00 ET | at Miami Coral Gables, Fla. | |