| Date | Game | |
| Mon Nov 2, 9:00 ET | vs Chattanooga Louisville, Ky. | W 84-70 |
| Sat Nov 7, 12:00 ET | vs Morehead State Louisville, Ky. | W 107-57 |
| Sun Nov 15, 1:00 ET | at Memphis | ESPN |
| Thu Nov 19, 8:00 ET | vs Stetson | ACCN |
| Tue Nov 24, 8:00 ET | vs Texas Tech | ESPN |
| Thu Nov 26 | vs Oregon or St. John's Las Vegas, Nev. | Michelob ULTRA Arena | |
| Fri Nov 27 | vs TBD Las Vegas, Nev. | Michelob ULTRA Arena | |
| Tue Dec 1, 9:00 ET | vs Texas Louisville, Ky. | ESPN2 |
| Sat Dec 5, 12:00 ET | vs Michigan Detroit, Mich. | Little Caesars Arena | |
| Sat Dec 12, 4:00 ET | at Kentucky Lexington, Ky. | ABC |
| Wed Dec 16, 9:00 ET | vs Long Island Louisville, Ky. | ACCN |
| Sat Dec 19, 1:30 ET | vs Eastern Michigan Louisville, Ky. | The CW |
| Wed Dec 30, 8:00 ET | at Virginia Tech Blacksburg, Va. | The CW |
| Sat Jan 2, 6:00 ET | vs Stanford Louisville, Ky. | ACCN |
| Tue Jan 5, 9:00 ET | vs North Carolina Louisville, Ky. | ESPN/U |
| Sat Jan 9, 2:15 ET | at SMU Dallas, Texas | The CW |
| Wed Jan 13, 7:00 ET | vs California Louisville, Ky. | ACCN |
| Sat Jan 16, 2:00 ET | at Syracuse Syracuse, N.Y. | |
| Tue Jan 19, 7:00 ET | vs Miami Louisville, Ky. | |
| Sat Jan 23, 4:00 ET | vs Baylor Indianapolis, Ind. | |
| Wed Jan 27, 7:00 ET | at Boston College Chestnut, Hill, Mass. | ACCN |
| Sat Jan 30, 12:00 ET | at Georgia Tech Atlanta, Ga. | ESPN/2 |
| Tue Feb 2, 9:00 ET | vs Pittsburgh Louisville, Ky. | ESPN/2 |
| Sat Feb 6, 3:00 ET | vs Wake Forest Louisville, Ky. | ACCN |
| Mon Feb 8, 6:00 ET | at North Carolina Chapel Hill | ESPN |
| Sat Feb 13, 12:00 ET | vs SMU Louisville, KY | ESPN/2 |
| Mon Feb 15, 7:00 ET | at Virginia Charlottesville, Va. | ESPN |
| Sun Feb 21, 4:00 ET | at Florida State Tallahassee, Fla. | ESPN/2 |
| Wed Feb 24, 7:00 ET | vs Duke Louisville, Ky. | ESPN |
| Tue Mar 2, 7:00 ET | at NC State Raleigh, NC | |
| Sat Mar 6, 12:00 ET | vs Clemson Louisville, Ky. | ESPN/U |