| Date | Game | |
| Thu Aug 24, 7:30 ET | vs Tulsa Louisville, Ky. | W 1-0 |
| Mon Aug 28, 7:30 ET | vs Bellarmine Louisville, Ky. | W 3-0 |
| Fri Sep 1, 7:00 ET | at UNC Greensboro Greensboro, N.C. | W 2-0 |
| Tue Sep 5, 8:00 ET | vs Kentucky Louisville, Ky. | W 4-2 |
| Fri Sep 8, 8:00 ET | at Syracuse Syracuse, NY | T 2-2 |
| Fri Sep 15, 8:00 ET | vs Virginia Tech Louisville, Ky. | L 1-2 |
| Tue Sep 19, 7:30 ET | at Evansville Evansville, Ind. | W 2-0 |
| Sun Sep 24, 7:00 ET | vs NC State Louisville, KY | W 5-2 |
| Fri Sep 29, 7:00 ET | at Virginia Charlottesville, Va. | L 0-3 |
| Mon Oct 2, 7:00 ET | vs Kansas City Louisville, Ky. | W 3-2 |
| Fri Oct 6, 7:00 ET | at Clemson Clemson, S.C. | L 0-4 |
| Tue Oct 10, 7:00 ET | vs Ohio State Louisville, Ky. | T 2-2 |
| Fri Oct 13, 7:00 ET | vs Boston College Louisville, Ky. | W 1-0 |
| Tue Oct 17, 7:00 ET | at Oakland Rochester, Mich. | W 4-0 |
| Sun Oct 22, 5:00 ET | at North Carolina Chapel Hill, NC | L 0-2 |
| Fri Oct 27, 7:00 ET | vs Wake Forest Louisville, Ky. | T 2-2 |
| Wed Nov 1, 8:00 ET | at Pitt Pittsburgh, PA | W 2-1 |
| Sun Nov 5, 8:00 ET | at Notre Dame South Bend, Ind. | W 4-3 |
| Wed Nov 8, 8:00 ET | at Clemson Clemson, SC | L 1-5 |
| Thu Nov 16, 7:00 ET | vs Dayton Louisville, KY | W 4-3 |
| Sun Nov 19, 2:00 ET | at West Virginia Morgantown, WV | L 0-1 |