| Date | Game | |
| Thu Aug 21, 5:00 ET | vs Southern Indiana Louisville, KY | W 6-0 |
| Mon Aug 25, 8:00 ET | at UAB Birmingham, AL | W 1-0 |
| Fri Aug 29, 6:00 ET | vs IU Indy Louisville, KY | W 4-0 |
| Fri Sep 5, 11:00 AM ET | vs Stanford Louisville, KY | W 1-0 |
| Tue Sep 9, 7:00 ET | at Ohio State Columbus, OH | W 1-0 |
| Sat Sep 13, 6:00 ET | vs Virginia Louisville, KY | L 0-1 |
| Fri Sep 19, 7:00 ET | at Notre Dame South Bend, Ind. | L 0-3 |
| Tue Sep 23, 7:00 ET | vs Kentucky Louisville, KY | T 2-2 |
| Fri Sep 26, 7:00 ET | at Duke University Durham, NC | L 0-1 |
| Fri Oct 3, 6:00 ET | vs University of North Carolina Louisville, KY | L 0-1 |
| Tue Oct 7, 6:00 ET | vs Belmont Louisville, KY | T 0-0 |
| Sat Oct 11, 5:00 ET | at Virginia Tech Blacksburg, VA | L 0-2 |
| Fri Oct 17, 7:00 ET | at Wake Forest University Winston-Salem, NC | T 1-1 |
| Tue Oct 21, 8:00 ET | at Lipscomb Nashville, TN | T 1-1 |
| Mon Oct 27, 6:00 ET | vs Evansville Louisville, KY | L 1-3 |
| Fri Oct 31, 6:00 ET | vs University of Pittsburgh Louisville, KY | T 0-0 |
| Wed Nov 5, 6:00 ET | at NC State Raleigh, NC | L 0-3 |