| Date | Game | |
| Wed Jan 18, 12:00 ET | vs UIC Louisville, KY | W 7-0 |
| Wed Jan 18, 5:00 ET | vs Bellarmine Louisville, KY | W 6-1 |
| Sun Jan 22, 12:00 ET | vs Northwestern Louisville, KY | W 4-0 |
| Sun Jan 22, 5:00 ET | vs Eastern Kentucky Louisville, KY | W 5-0 |
| Sun Jan 29, 11:00 AM ET | vs Miami Louisville, KY | W 4-1 |
| Mon Jan 30, 2:30 ET | at Georgia Athens, Ga. | L 1-4 |
| Fri Feb 10, 4:00 ET | vs Kentucky Louisville, KY | L 3-4 |
| Sun Feb 12, 12:00 ET | vs Michigan State Louisville, KY | W 6-1 |
| Sun Feb 12, 5:00 ET | vs Tennessee State Louisville, KY | W 7-0 |
| Fri Feb 17, 5:00 ET | at Indiana Bloomington, IN | W 4-0 |
| Sat Feb 25 | vs Belmont Louisville, KY | W 7-0 |
| Fri Mar 3, 2:00 ET | vs Duke Louisville, KY | L 2-4 |
| Sun Mar 5, 1:00 ET | vs North Carolina Louisville, KY | L 0-4 |
| Fri Mar 10, 4:00 ET | vs Virginia Louisville, KY | L 2-4 |
| Sun Mar 12, 12:00 ET | vs Virginia Tech Louisville, KY | W 6-1 |
| Fri Mar 17, 5:30 ET | at Florida State Tallahassee, FL | L 0-4 |
| Sun Mar 19, 12:00 ET | at Miami Coral Gables, FL | L 1-4 |
| Fri Mar 24, 4:00 ET | at Wake Forest Winston-Salem, NC | L 1-4 |
| Sun Mar 26, 12:00 ET | at NC State Raleigh, NC | W 4-3 |
| Sun Mar 26, 12:00 ET | at NC State Raleigh, NC | W 4-3 |
| Fri Mar 31, 12:00 ET | vs Boston College Louisville, KY | W 7-0 |
| Sun Apr 2, 12:00 ET | at Michigan Ann Arbor, MI | L 3-4 |
| Fri Apr 7, 5:00 ET | at Georgia Tech Atlanta, GA | W 4-3 |
| Sun Apr 9 | at Clemson Clemson, SC | W 4-2 |
| Thu Apr 13, 3:00 ET | vs Notre Dame Louisville, KY | W 4-0 |
| Sun Apr 16, 3:30 ET | vs Middle Tennessee Louisville, KY | L 1-4 |
| Thu Apr 20, 6:00 ET | vs Notre Dame Cary, NC | W 4-3 |
| Fri Apr 21, 6:00 ET | vs Duke | L 0-4 |
| Sat May 6, 10:00 AM ET | vs Texas Tech Columbus, Ohio | W 4-3 |
| Sun May 7, 12:00 ET | at Ohio State Columbus, OH | L 0-4 |