| Date | Game | |
| Wed Jan 17, 12:00 ET | vs Xavier Louisville, Ky. | W 6-1 |
| Wed Jan 17, 5:00 ET | vs Bellarmine Louisville, Ky. | W 6-1 |
| Sun Jan 21 | at Northwestern Evanston, Ill. | W 4-3 |
| Sat Jan 27 | vs LSU Columbia, S.C. | L 2-4 |
| Sun Jan 28 | vs Clemson | W 4-0 |
| Fri Feb 2, 5:00 ET | at Kentucky Lexington, Ky. | L 1-6 |
| Fri Feb 9, 5:00 ET | vs Cornell Louisville, Ky. | W 6-1 |
| Sun Feb 11, 12:00 ET | vs Harvard Louisville, Ky. | L 3-4 |
| Sat Feb 17, 1:00 ET | vs Butler Louisville, Ky. | W 7-0 |
| Sat Feb 17, 5:00 ET | vs Belmont Louisville, Ky. | W 6-1 |
| Sat Feb 24, 12:00 ET | vs Indiana Louisville, Ky. | W 6-1 |
| Sat Feb 24, 4:00 ET | vs IUPUI Louisville, Ky. | W 7-0 |
| Fri Mar 1, 5:00 ET | vs Florida State Louisville, KY | L 2-4 |
| Sun Mar 3, 12:00 ET | vs Eastern Kentucky Louisville, Ky. | W 4-0 |
| Sun Mar 3, 4:00 ET | vs Miami Louisville, Ky. | W 4-3 |
| Sun Mar 10 | at Middle Tennessee Murfreesboro, Tenn. | L 0-4 |
| Fri Mar 15, 3:00 ET | at Virginia Charlottesville, Va. | L 0-7 |
| Sun Mar 17, 1:00 ET | at Virginia Tech Blacksburg, Va. | W 4-3 |
| Fri Mar 22, 3:00 ET | vs Wake Forest Louisville, Ky. | L 3-4 |
| Sun Mar 24 | vs NC State Louisville, KY | L 0-4 |
| Sun Mar 24, 12:00 ET | vs Tennessee State Louisville, Ky. | W 6-1 |
| Fri Mar 29, 5:00 ET | at Duke University Durham, N.C. | L 1-6 |
| Sun Mar 31, 12:15 ET | at North Carolina Chapel Hill | L 0-4 |
| Fri Apr 5, 5:00 ET | vs Georgia Tech Louisville, KY | L 2-4 |
| Sun Apr 7, 12:00 ET | vs Clemson Louisville, Ky. | L 0-4 |
| Wed Apr 10 | at Notre Dame South Bend, Ind. | L 0-4 |
| Sun Apr 14, 10:00 AM ET | at Boston College Weymouth, MA | W 6-1 |
| Thu Apr 18, 12:30 ET | vs Georgia Tech Cary, N.C. | L 0-4 |