| Date | Game | |
| Fri Feb 10, 11:00 AM ET | vs South Alabama Clearwater, FL | W 4-2 |
| Fri Feb 10, 1:30 ET | vs Kentucky Clearwater, FL | L 0-8 |
| Sat Feb 11, 1:30 ET | vs Southern University Clearwater, FL | W 10-0 |
| Sat Feb 11, 4:00 ET | vs Missouri Clearwater, FL | W 4-0 |
| Sun Feb 12, 10:00 AM ET | vs Howard Clearwater, FL | W 8-0 |
| Fri Feb 17, 1:00 ET | vs Illinois Atlanta, GA | L 1-6 |
| Sat Feb 18, 10:00 AM ET | vs Wisconsin Atlanta, GA | W 2-0 |
| Sat Feb 18, 12:30 ET | vs Illinois Atlanta, GA | L 1-2 |
| Sun Feb 19, 10:00 AM ET | vs Wisconsin Atlanta, GA | W 2-1 |
| Fri Feb 24, 7:00 ET | at UCF Orlando, FL | L 3-4 |
| Sat Feb 25, 11:30 AM ET | vs Columbia Orlando, FL | W 8-2 |
| Sat Feb 25, 2:00 ET | vs Bradley Orlando, FL | W 8-0 |
| Sun Feb 26, 11:00 AM ET | vs Purdue Orlando, FL | W 4-3 |
| Sun Feb 26, 1:00 ET | at UCF Orlando, FL | W 15-5 |
| Tue Feb 28, 5:00 ET | vs Bellarmine Louisville, KY | W 13-0 |
| Thu Mar 2, 4:00 ET | vs Northern Kentucky Louisville, KY | W 7-0 |
| Sat Mar 4, 10:00 AM ET | vs Toledo Louisville, KY | W 8-4 |
| Sat Mar 4, 5:30 ET | vs Northwestern Louisville, KY | L 1-4 |
| Sun Mar 5, 3:00 ET | vs Northwestern Louisville, KY | L 1-11 |
| Sun Mar 5, 5:30 ET | vs Northern Kentucky Louisville, KY | W 2-0 |
| Fri Mar 10, 6:00 ET | at Duke Durham, N.C. | L 6-9 |
| Sat Mar 11, 2:00 ET | at Duke Durham, N.C. | L 3-5 |
| Sat Mar 11, 4:30 ET | at Duke Durham, N.C. | W 13-9 |
| Tue Mar 14, 3:00 ET | at Charlotte Charlotte, N.C. | L 2-10 |
| Fri Mar 17, 3:00 ET | vs Pitt Louisville, KY | W 12-2 |
| Fri Mar 17, 5:30 ET | vs Pitt Louisville, KY | W 5-4 |
| Fri Mar 17, 5:30 ET | vs Pitt Louisville, KY | W 5-4 |
| Fri Mar 17, 5:30 ET | vs Pitt Louisville, KY | W 5-4 |
| Tue Mar 21, 6:00 ET | at Eastern Kentucky Richmond, KY | W 10-1 |
| Sat Mar 25, 4:00 ET | vs NC State Louisville, KY | W 7-4 |
| Sat Mar 25, 6:30 ET | vs NC State Louisville, KY | W 13-0 |
| Sun Mar 26, 12:30 ET | vs NC State Louisville, KY | W 3-2 |
| Wed Mar 29, 6:30 ET | at Kentucky Lexington, KY | L 4-7 |
| Sat Apr 1, 10:30 AM ET | at Syracuse Syracuse, NY | W 5-3 |
| Sat Apr 1, 12:30 ET | at Syracuse Syracuse, NY | W 8-0 |
| Thu Apr 6, 6:00 ET | vs Notre Dame Louisville, KY | L 0-1 |
| Fri Apr 7, 6:00 ET | vs Notre Dame Louisville, KY | L 6-13 |
| Sat Apr 8, 2:00 ET | vs Notre Dame Louisville, KY | W 6-2 |
| Tue Apr 11, 6:00 ET | at Indiana Bloomington, IN | L 5-10 |
| Sat Apr 15, 4:00 ET | vs Oklahoma Oxford, OH | L 1-10 |
| Sun Apr 16, 1:00 ET | vs Oakland Louisville, KY | W 10-5 |
| Wed Apr 19, 7:00 ET | at Western Kentucky Bowling Green, KY | W 3-2 |
| Fri Apr 21, 6:00 ET | at Virginia Charlottesville, VA | W 5-3 |
| Sat Apr 22, 6:00 ET | at Virginia Charlottesville, VA | W 6-4 |
| Sun Apr 23, 4:00 ET | at Virginia Charlottesville, VA | W 9-2 |
| Fri Apr 28, 6:00 ET | vs Boston College Louisville, KY | W 10-2 |
| Sat Apr 29, 2:00 ET | vs Boston College Louisville, KY | W 8-0 |
| Sun Apr 30, 12:00 ET | vs Boston College Louisville, KY | W 8-0 |
| Fri May 5, 6:00 ET | at Florida State Tallahassee, FL | L 4-6 |
| Sat May 6, 2:00 ET | at Florida State Tallahassee, FL | L 4-6 |
| Sun May 7, 12:00 ET | at Florida State Tallahassee, FL | L 1-2 |
| Thu May 11, 1:30 ET | vs Virginia Tech South Bend, IN / ACC Championship | L 8-10 |
| Fri May 19, 3:00 ET | vs Indiana Knoxville, Tenn. / NCAA Regional | L 3-4 |
| Sun May 21, 2:05 ET | vs Indiana Knoxville, Tenn. / NCAA Regional | L 2-4 |