| Date | Game | |
| Fri Feb 6, 4:30 ET | vs Stony Brook Miami, FL | W 7-4 |
| Fri Feb 6, 7:00 ET | at FIU Miami, FL | L 5-7 |
| Sat Feb 7, 11:30 AM ET | vs Texas A&M - Corpus Christi Miami, FL | W 13-5 |
| Sat Feb 7, 4:30 ET | vs Lehigh Miami, FL | W 4-0 |
| Sun Feb 8, 11:30 AM ET | at FIU Miami, FL | L 5-8 |
| Fri Feb 13, 11:00 AM ET | vs Boston University Columbia, SC | W 3-0 |
| Fri Feb 13, 1:30 ET | at South Carolina Columbia, SC | L 1-9 |
| Sat Feb 14, 10:00 AM ET | vs Kennesaw State Columbia, SC | W 4-0 |
| Sat Feb 14, 12:30 ET | vs UC Riverside Columbia, SC | W 5-3 |
| Tue Feb 17, 6:30 ET | vs Bellarmine Louisville, KY | W 10-2 |
| Fri Feb 20, 2:30 ET | vs Buffalo Fort Myers, FL | W 10-6 |
| Fri Feb 20, 4:45 ET | at Florida Gulf Coast Fort Myers, FL | W 3-2 |
| Sat Feb 21, 12:15 ET | vs Wisconsin Fort Myers, FL | W 10-5 |
| Sat Feb 21, 2:30 ET | vs UConn Fort Myers, FL | W 10-2 |
| Sun Feb 22, 9:00 AM ET | vs Buffalo Fort Myers, FL | W 4-1 |
| Fri Feb 27, 6:00 ET | vs Stanford Louisville, KY | W 8-3 |
| Sat Feb 28, 1:00 ET | vs Stanford Louisville, KY | L 8-10 |
| Sun Mar 1, 6:00 ET | vs Stanford Louisville, KY | W 9-8 |
| Tue Mar 3, 6:00 ET | vs Northern Kentucky Louisville, KY | W 10-6 |
| Fri Mar 6, 1:30 ET | vs Ball State Louisville, KY | L 5-7 |
| Sat Mar 7, 9:00 AM ET | vs Ball State Louisville, KY | W 8-1 |
| Sat Mar 7, 7:00 ET | vs Illinois Louisville, KY | W 8-6 |
| Sun Mar 8, 4:30 ET | vs Illinois Louisville, KY | W 13-5 |
| Tue Mar 10, 6:00 ET | vs Evansville Louisville, KY | W 5-4 |
| Fri Mar 13, 4:00 ET | at Clemson Clemson, SC | L 6-8 |
| Sat Mar 14, 1:00 ET | at Clemson Clemson, SC | L 0-4 |
| Sun Mar 15, 12:00 ET | at Clemson Clemson, SC | W 7-6 |
| Wed Mar 18, 7:00 ET | at Western Kentucky Bowling Green, KY | W 13-4 |
| Fri Mar 20, 12:00 ET | vs Campbell Columbus, OH | W 8-2 |
| Sat Mar 21, 12:00 ET | vs Indiana State Columbus, OH | W 12-1 |
| Sat Mar 21, 2:30 ET | at Ohio State Columbus, OH | W 6-5 |
| Sun Mar 22, 10:00 AM ET | vs Campbell Columbus, OH | W 12-0 |
| Wed Mar 25, 5:30 ET | at Kentucky Lexington, KY | W 8-7 |
| Fri Mar 27, 6:00 ET | vs Georgia Tech Louisville, KY | W 8-5 |
| Sat Mar 28, 1:00 ET | vs Georgia Tech Louisville, KY | W 6-5 |
| Sun Mar 29, 12:00 ET | vs Georgia Tech Louisville, KY | W 3-1 |
| Tue Mar 31, 6:00 ET | at Eastern Kentucky Richmond, KY | W 12-4 |
| Thu Apr 2, 5:00 ET | at California Saratoga, CA | L 5-7 |
| Fri Apr 3, 5:00 ET | at California Saratoga, CA | W 6-3 |
| Sat Apr 4, 3:00 ET | at California Saratoga, CA | W 12-2 |
| Fri Apr 10, 5:00 ET | at Notre Dame South Bend, IN | L 2-5 |
| Sat Apr 11, 1:00 ET | at Notre Dame South Bend, IN | W 8-5 |
| Sun Apr 12, 1:00 ET | at Notre Dame South Bend, IN | W 13-5 |
| Wed Apr 15, 8:00 ET | vs Indiana Louisville, KY | W 8-7 |
| Fri Apr 17, 5:00 ET | vs Pitt Louisville, KY | W 9-1 |
| Fri Apr 17, 7:00 ET | vs Pitt Louisville, KY | W 10-2 |
| Sun Apr 19, 4:00 ET | vs Pitt Louisville, KY | W 14-0 |
| Wed Apr 22, 6:00 ET | vs Kentucky Louisville, KY | L 8-12 |
| Fri Apr 24, 4:00 ET | vs Syracuse Louisville, KY | W 13-5 |
| Sat Apr 25, 1:00 ET | vs Syracuse Louisville, KY | W 5-1 |
| Sun Apr 26, 12:00 ET | vs Syracuse Louisville, KY | W 13-7 |
| Fri May 1, 6:00 ET | at NC State Raleigh, NC | W 5-1 |
| Sat May 2, 6:00 ET | at NC State Raleigh, NC | L 6-10 |
| Sun May 3, 1:00 ET | at NC State Raleigh, NC | W 8-3 |
| Wed May 6 | vs ACC Softball Championship Charlottesville, VA | |
| Wed May 6, 1:30 ET | vs NC State Charlottesville, VA (ACC Championship) | W 6-5 |
| Thu May 7, 1:30 ET | vs Stanford Charlottesville, VA (ACC Championship) | ACCN |