| Date | Game | |
| Mon Nov 4, 2:30 ET | vs UCLA | |
| Fri Nov 8, 7:00 ET | vs Southern Indiana Louisville, Ky. | W 75-51 |
| Tue Nov 12, 7:00 ET | at UT Martin Martin, TN | W 86-64 |
| Sat Nov 16, 6:00 ET | at Kentucky Lexington, KY | L 61-71 |
| Thu Nov 21, 7:00 ET | vs Morehead State Louisville, Ky. | W 107-70 |
| Sun Nov 24, 1:00 ET | vs South Florida Orlando, Fla. | W 64-60 |
| Sat Nov 30, 3:00 ET | at Colorado Boulder, CO | W 79-71 |
| Wed Dec 4, 5:00 ET | vs Oklahoma Louisville, Ky. | L 72-78 |
| Sat Dec 7, 9:00 ET | vs UConn Brooklyn, NY (Barclays Center) | L 52-85 |
| Thu Dec 12, 7:00 ET | vs Grambling State Louisville, Ky. | W 96-57 |
| Sun Dec 15, 1:00 ET | vs NC State Louisville, Ky. | L 42-72 |
| Sat Dec 21, 5:00 ET | at Memphis Memphis, TN | W 87-68 |
| Sun Dec 29, 2:00 ET | at Boston College Chestnut Hill, Mass. | W 86-73 |
| Thu Jan 2, 7:00 ET | vs Miami Louisville, Ky. | W 74-56 |
| Sun Jan 5, 4:00 ET | at Wake Forest Winston-Salem, NC | W 81-76 |
| Thu Jan 9, 6:00 ET | at Pitt Pittsburgh, PA | W 65-56 |
| Sun Jan 12, 4:00 ET | vs Georgia Tech Louisville, Ky. | W 69-60 |
| Thu Jan 16, 7:00 ET | vs Syracuse Louisville, Ky. | W 72-62 |
| Sun Jan 19, 4:00 ET | at Virginia Tech Blacksburg, VA | L 65-70 |
| Sun Jan 26, 2:00 ET | at Virginia Charlottesville, VA | W 68-65 |
| Thu Jan 30, 8:00 ET | at SMU Dallas, Texas | W 80-75 |
| Sun Feb 2, 12:00 ET | vs Notre Dame | |
| Thu Feb 6, 8:00 ET | vs Cal | |
| Sun Feb 9, 12:00 ET | vs Stanford | |
| Thu Feb 13, 6:00 ET | at Florida State Tallahassee, Fla. | W 83-69 |
| Thu Feb 20, 7:00 ET | at Duke Durham, N.C. | W 70-62 |
| Sun Feb 23, 2:00 ET | vs North Carolina | |
| Thu Feb 27, 6:00 ET | vs Clemson | |
| Sun Mar 2, 12:00 ET | at Notre Dame South Bend, Ind. | L 59-72 |
| Thu Mar 6, 7:30 ET | vs Clemson Greensboro, N.C. | W 70-68 |
| Fri Mar 7, 7:30 ET | vs Duke Greensboro, N.C. | L 48-61 |
| Fri Mar 21, 6:00 ET | vs Nebraska Fort Worth, Texas | W 63-58 |
| Sun Mar 23, 6:00 ET | at TCU Fort Worth, TX | L 70-85 |