| Date | Game | |
| Tue Nov 4, 5:30 ET | vs UConn Annapolis, Md. | L 66-79 |
| Sun Nov 9, 2:00 ET | vs Northern Kentucky | |
| Wed Nov 12, 7:00 ET | vs Colorado | |
| Sun Nov 16, 3:00 ET | at Clemson Clemson, SC | W 65-54 |
| Wed Nov 19, 8:00 ET | vs Morehead State | |
| Sat Nov 22, 2:00 ET | vs Kentucky | |
| Fri Nov 28, 7:00 ET | vs Eastern Illinois | |
| Sat Nov 29, 3:30 ET | vs East Tennessee State Louisville, KY | W 88-50 |
| Sun Nov 30, 2:00 ET | vs Bellarmine | |
| Thu Dec 4, 7:00 ET | vs South Carolina Louisville, KY | |
| Sun Dec 7, 12:00 ET | vs New Hampshire Louisville, KY | |
| Wed Dec 10, 9:00 ET | vs Ball State Louisville, KY | |
| Sun Dec 14, 4:00 ET | at North Carolina Chapel Hill, N.C. | |
| Wed Dec 17, 6:00 ET | vs Eastern Kentucky Louisville, KY | |
| Sat Dec 20, 11:00 AM ET | vs Tennessee Brooklyn, NY | |
| Thu Jan 1, 2:00 ET | vs SMU Louisville, Ky. | |
| Sun Jan 4, 4:00 ET | vs Virginia Tech Louisville, KY | |
| Thu Jan 8, 7:00 ET | at Miami Coral Gables, FL | |
| Sun Jan 11, 2:00 ET | vs Pitt Louisville, KY | |
| Thu Jan 15, 6:00 ET | at Notre Dame South Bend, Ind. | |
| Sun Jan 18, 1:00 ET | at NC State Raleigh, N.C. | |
| Sun Jan 25, 2:00 ET | vs Boston College Louisville, KY | |
| Thu Jan 29, 8:00 ET | at Stanford Stanford, CA | |
| Sun Feb 1, 2:00 ET | at California Berkeley, CA | |
| Thu Feb 5, 7:00 ET | vs Duke Louisville, KY | |
| Sun Feb 8, 12:00 ET | at Syracuse Syracuse, NY | |
| Thu Feb 12, 7:00 ET | vs Wake Forest Louisville, KY | |
| Sun Feb 15, 6:00 ET | vs Florida State Louisville, KY | |
| Sun Feb 22, 12:00 ET | vs Virginia Louisville, KY | |
| Thu Feb 26, 6:00 ET | at Georgia Tech Atlanta, GA | |
| Sun Mar 1, 4:00 ET | vs Notre Dame Louisville, KY | |