| Date | Game | |
| Mon Nov 2, 5:00 ET | vs Bellarmine Louisville, KY | |
| Wed Nov 4, 8:00 ET | vs Stetson Louisville, KY | |
| Sun Nov 8, 4:00 ET | at Southern Indiana Evansville, IN | |
| Tue Nov 10, 7:00 ET | vs Lindenwood Louisville, KY | |
| Thu Nov 12, 6:30 ET | at Ball State Muncie, IN | |
| Sun Nov 15, 5:30 ET | vs UConn Louisville, KY | |
| Tue Nov 17, 6:00 ET | vs Tennessee State Louisville, KY | |
| Sat Nov 21, 11:30 ET | at Alaska Anchorage Anchorage, AK | |
| Sun Nov 22 | vs Chicago State/Seattle Anchorage, AK | |
| Fri Nov 27, 12:00 ET | vs Akron Louisville, KY | |
| Sun Nov 29, 12:00 ET | vs ETSU Louisville, KY | |
| Wed Dec 2, 9:15 ET | at Texas Austin, TX | |
| Sun Dec 6, 4:00 ET | vs Eastern Kentucky Louisville, KY | |
| Wed Dec 9, 9:00 ET | at Kentucky Lexington, KY | |
| Sun Dec 13, 2:00 ET | vs Miami Louisville, KY | |
| Thu Dec 17, 7:00 ET | vs Northern Kentucky Louisville, KY | |
| Sun Dec 20, 5:30 ET | vs Clemson Louisville, KY | |
| Thu Dec 31, 12:00 ET | at Boston College Chestnut Hill, MA | |
| Sun Jan 3, 2:00 ET | vs Cal Louisville, KY | |
| Thu Jan 7, 6:00 ET | at Florida State Tallahassee, FL | |
| Sun Jan 10, 3:00 ET | vs North Carolina Louisville, Ky. | ESPN/2 |
| Thu Jan 14, 7:00 ET | at Pitt Pittsburgh, Pa. | |
| Sun Jan 17, 2:00 ET | at Virginia Tech Blacksburg, VA | |
| Thu Jan 21, 7:00 ET | vs Notre Dame Louisville, KY | |
| Sun Jan 24, 2:00 ET | at SMU Dallas, Texas | |
| Thu Jan 28, 7:00 ET | vs Stanford Louisville, KY | |
| Thu Feb 4, 6:00 ET | at Wake Forest Winston-Salem, NC | |
| Sun Feb 7, 2:00 ET | at Virginia Charlottesville, VA | ESPN/2 |
| Thu Feb 11, 6:00 ET | vs Syracuse Louisville, KY | |
| Sun Feb 14, 2:00 ET | vs Georgia Tech Louisville, KY | |
| Thu Feb 18, 7:00 ET | at Duke Durham, NC | |
| Sun Feb 21, 2:00 ET | vs NC State Louisville, Ky. | |
| Sun Feb 28, 12:00 ET | at Notre Dame South Bend, Ind. | |