| Date | Game | |
| Fri Feb 11, 4:00 ET | at Colorado Boulder, CO | L 13-14 |
| Sun Feb 13, 1:00 ET | at Denver Denver, CO | L 9-19 |
| Fri Feb 18, 12:00 ET | vs Marquette Louisville, KY | W 18-9 |
| Sun Feb 20, 11:00 AM ET | vs Central Michigan Louisville, KY | W 18-7 |
| Sat Feb 26, 12:00 ET | vs Virginia Tech Louisville, Ky. | W 14-11 |
| Tue Mar 1, 3:00 ET | vs Butler Louisville, KY | W 22-8 |
| Sat Mar 5, 12:00 ET | vs Boston College Louisville, KY | L 10-19 |
| Wed Mar 9, 4:00 ET | at Cincinnati Cincinnati OH | W 16-9 |
| Sun Mar 13, 1:00 ET | at North Carolina Chapel Hill, NC | L 8-21 |
| Thu Mar 17, 8:00 ET | at Duke Durham, N.C. | L 12-16 |
| Sat Mar 26, 12:00 ET | vs Virginia Louisville, KY | L 11-12 |
| Thu Mar 31, 7:00 ET | vs Ohio State Louisville, KY | L 12-13 |
| Tue Apr 5, 12:00 ET | vs Vanderbilt Louisville, KY | W 15-6 |
| Sat Apr 9, 12:00 ET | at Pittsburgh Pittsburgh, PA | L 10-17 |
| Sat Apr 16, 12:00 ET | at Syracuse Syracuse, N.Y. | L 13-23 |
| Mon Apr 18, 12:00 ET | at Niagara Niagara Falls, NY | W 19-10 |
| Sat Apr 23, 12:00 ET | vs Notre Dame Louisville, KY | L 14-15 |
| Wed Apr 27, 2:00 ET | vs Pitt ACC Championship / Notre Dame, Ind. | L 10-13 |