| Date | Game | |
| Fri Feb 10, 1:00 ET | vs Denver Louisville, KY | L 4-5 |
| Sun Feb 12, 12:00 ET | vs Colorado Louisville, KY | W 12-5 |
| Sun Feb 19, 1:00 ET | vs Lindenwood Louisville, KY | W 14-7 |
| Sat Feb 25, 1:00 ET | at Virginia Charlottesville, VA | L 9-19 |
| Mon Feb 27, 2:00 ET | at Vanderbilt Nashville, TN | W 15-12 |
| Sun Mar 5, 4:00 ET | vs Pittsburgh Louisville, KY | W 12-9 |
| Sat Mar 11, 11:00 AM ET | at Boston College Chestnut Hill, MA | L 8-19 |
| Thu Mar 16, 1:00 ET | vs North Carolina Louisville, KY | L 7-20 |
| Sun Mar 19, 1:00 ET | at Marquette Milwaukee, WI | L 11-15 |
| Sat Mar 25, 12:00 ET | vs Syracuse Louisville, KY | L 5-17 |
| Tue Mar 28, 4:00 ET | at Ohio State Columbus, OH | L 6-16 |
| Sat Apr 1, 1:00 ET | at Clemson Clemson, SC | L 8-19 |
| Sat Apr 8, 12:00 ET | at Virginia Tech Blacksburg, Va. | L 7-17 |
| Wed Apr 12, 2:00 ET | vs Cincinnati Louisville, KY | L 12-13 |
| Sat Apr 15, 1:00 ET | vs Duke Louisville, KY | W 14-13 |
| Thu Apr 20, 7:00 ET | at Notre Dame South Bend, Ind. | L 9-15 |
| Sun Apr 23, 2:00 ET | vs Duke Louisville, KY | L 11-12 |