| Date | Game | |
| Fri Feb 7, 12:00 ET | vs Denver Louisville, Ky. | W 10-8 |
| Wed Feb 12, 12:00 ET | vs Cincinnati Louisville, Ky. | W 11-9 |
| Sat Feb 15, 10:00 AM ET | at Ohio State Columbus, OH | L 6-9 |
| Mon Feb 17, 1:00 ET | at Marquette Milwaukee, WI | L 10-13 |
| Sat Feb 22, 3:00 ET | at Cal Berkeley, CA | W 10-9 |
| Fri Feb 28, 12:00 ET | vs North Carolina Louisville, Ky. | L 4-20 |
| Wed Mar 5, 1:00 ET | at Vanderbilt Nashville, TN | W 13-9 |
| Sat Mar 8, 12:00 ET | vs Virginia Tech Louisville, Ky. | L 7-16 |
| Sat Mar 15, 12:00 ET | at Boston College Chestnut Hill, Mass. | L 5-18 |
| Wed Mar 19, 6:00 ET | at Xavier Cincinnati, Ohio | W 19-6 |
| Sun Mar 23, 12:00 ET | at Clemson Clemson, S.C. | L 2-14 |
| Sat Mar 29, 12:00 ET | vs Stanford Louisville, Ky. | L 2-15 |
| Tue Apr 1, 12:00 ET | vs Liberty Louisville, Ky. | W 12-10 |
| Sat Apr 5, 12:00 ET | at Virginia Charlottesville, Va. | L 3-17 |
| Wed Apr 9, 12:00 ET | vs Kent State Louisville, Ky. | W 17-3 |
| Sat Apr 12, 2:00 ET | vs Duke Louisville, Ky. | L 7-17 |
| Thu Apr 17, 3:00 ET | at Notre Dame Notre Dame, Ind. | L 6-17 |