| Date | Game | |
| Tue Feb 10, 12:00 ET | vs Ohio State Louisville, KY | L 10-11 |
| Sat Feb 14, 11:00 AM ET | at Virginia Tech Blacksburg, VA | L 11-16 |
| Wed Feb 18, 12:00 ET | vs Kent State Louisville, KY | W 9-5 |
| Sun Feb 22, 12:00 ET | at North Carolina Chapel Hill, NC | L 3-24 |
| Wed Feb 25, 12:00 ET | vs Canisius Louisville, KY | W 20-13 |
| Sat Feb 28, 12:00 ET | vs Syracuse Louisville, KY | L 10-13 |
| Wed Mar 4, 12:00 ET | vs Florida State Louisville, KY | W 15-5 |
| Thu Mar 12, 12:00 ET | at Cincinnati Cincinnati OH | W 11-10 |
| Sat Mar 14, 12:00 ET | at Duke University Durham, NC | L 14-16 |
| Sat Mar 21, 12:00 ET | vs California Louisville, KY | W 12-5 |
| Wed Mar 25, 12:00 ET | vs Vanderbilt Louisville, KY | W 5-4 |
| Sat Mar 28, 12:00 ET | vs Virginia Louisville, KY | L 10-12 |
| Sat Apr 4, 4:00 ET | at Stanford Stanford, CA | L 5-22 |
| Sat Apr 11, 12:00 ET | vs Pittsburgh Louisville, KY | L 14-15 |
| Thu Apr 16, 5:00 ET | at Notre Dame South Bend, Ind. | L 3-18 |